-
-
Acetaminophen
N-acetylcysteine (replenishes glutathione)
-
Salicylates
- NaHCO3 (alkalinize urine)
- dialysis
-
Amphetamines (basic)
NH4Cl (acidify urine)
-
Acetylcholinesterase inhibitors, organophosphates
-
Antimuscarinic, anticholinergic agents
- Physostigmine salicylate
- control hyperthermia
-
-
Digitalis
- Normalize K+
- Lidocaine
- Anti-dig Fab fragments
- Mg2+
- (KLAM)
-
-
Lead
- CaEDTA
- dimercaprol
- succimer
- penicillamine
-
Mercury, arsenic, gold
- Dimercaprol (BAL)
- succimer
-
Copper, arsenic, gold
Penicillamine
-
Cyanide
- Nitrite + thiosulfate
- hydroxocobalamin
-
-
-
Methanol, ethylene glycol (antifreeze)
- Fomepizole > ethanol
- dialysis
-
Opioids
Naloxone/naltrexone
-
Benzodiazepines
Flumazenil
-
TCAs
NaHCO3 (plasma alkalinization)
-
-
Warfarin
- Vitamin K
- Fresh frozen plasma
-
tPA, streptokinase, urokinase
Aminocaproic acid
-
-
Drug reactions
Cardiovascular
- Coronary vasospasm: cocaine, sumatriptan, ergot alkaloid
- Cutaneous flushing: Vancomycin, Adenosine, Niacin, Ca2+ channel blockers (VANC)
- Dilated cardiomyopathy: Doxorubicin (Adriamycin), daunorubicin
- Torsades de pointes: Class III (sotalol) and class IA (quinidine) antiarrhythmics
-
Drug reactions
Hematologic
- Agranulocytosis: Clozapine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone
- **Agranulocytosis Could Certainly Cause Pretty Major Damage
- Aplastic anemia: Chloramphenicol, benzen, NSAIDs, propylthiouracil, methimazole
- Direct Coombs-positive hemolytic anemia: Methyldopa, penicillin
- Gray baby syndrome: Chloramphenicol
- Hemolysis in G6PD-deficient patients: Isoniazid (INH), Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin
- **Hemolysis IS PAIN
- Megaloblastic anemia: Phenytoin, Methotrexate, Sulfa drugs
- **Having a blast with PMS
-
Drug reactions
Respiratory
- Cough: ACE inhibitors
- Pulmonary fibrosis: BLeomycin, Amiodarone, Busulfan
- *It's hard to BLAB when you have pulmonary fibrosis
-
Drug reactions
GI
- Acute cholestatic hepatitis, jaundice: Erythromycin
- Focal to massive hepatic necrosis: Halothane, Amanita phalloides, Valproic acid, Acetaminophen
- **Liver "HAVAc"
- Hepatitis: INH
- Pseudomembranous colitis: Clindamycin, ampicillin
-
Drug reactions
Reproductive/endocrine
- Adrenocortical insufficiency: Glucocorticoid withdrawal (HPA suppression)
- Gynecomastia: Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole
- **Some Drugs Create Awkward Knockers
- Hot flashes: Tamoxifen, clomiphene
- Hyperglycemia: Niacin, tacrolimus, protease inhibitors, HCTZ, corticosteroids
- Hypothyroidism: Lithium, amiodarone, sulfonamides
-
Drug reactions
Musculoskeletal/connective tissue
- Fat redistribution: Glucocorticoids, protease inhibitors
- Gingival hyperplasia: Phenytoin, verapamil
- Gout: Furosemide, thiazides, niacin, cyclosporine
- Myopathies: Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-α, Penicillamine, Statins, Glucocorticoids
- **Fish N CHIPS Give you myopathies
- Osteoporosis: corticosteroids, heparin
- Photosensitivity: sulfonamides, Amiodarone, Tetracycline
- **SAT for a photo
- Rash (Stevens-Johnson syndrome): Penicillin, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital
- **Bad rash after a PEC SLAPP
- SLE-like syndrome: Hydralazine, INH, Procainamide, Phenytoin
- **It's not HIPP to have lupus
- Teeth (kids): Tetracyclines
- Tendonitis, tendon rupture, and cartilage damage: Fluoroquinolones
-
Drug reactions
Renal/GU
- Diabetes insibipidus: Lithium, demeclocycline
- Fanconi's syndrome: Expired tetracycline
- Hemorrhagic cystitis: Cyclophosphamide, ifosfamide (prevented by coadministering with mesna)
- Interstitial nephritis: Methicillin, NSAIDs, furosemide
- SIADH: Carbamazepine, cyclophosphamide
-
Drug reactions
Neurologic
- Cinchonism: Quinidine, quinine
- Parkinson-like syndrome: Antipsychotics, reserpine, metoclopramide
- Seizures: Isoniazid, Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide
- **with seizures, I BITE My tongue
- Tardive dyskinesia: Antipsychotics
-
Drug interactions
Multiorgan
- Antimuscarinic: Atropine, TCAs, H1-blockers, neuroleptics
- Disulfiram-like reaction: Metronidazole, certain cephalosporins, procarbazine, 1st generation sulfonylureas
- Nephrotoxicity/ototoxicity: aminoglycosides, vancomycin, loop diuretics, cisplatin
-
P-450 interactions
inducers
- Modafinil
- Barbiturates
- St. John's wort
- Phenytoin
- Rifampin
- Griseofulvin
- Carbamazepine
- Chronic alcohol use
- **Momma Barb Steals Phen-phen and Refuses Greasy Carbs Chronically
-
P-450 interactions
inhibitors
- Macrolides
- Amiodarone
- Grapefruit juice
- Isoniazid
- Cimetidine
- Ritonavir
- Acute alcohol abuse
- Ciprofloxacin
- Ketoconazole
- Sulfonamides
- Gemfibrozil
- Quinidine
- MAGIC RACKS in GQ
-
Sulfa drugs
- Probenecid
- Furosemide
- Acetazolamide
- Celecoxib
- Thiazides
- Sulfonamide antibiotics
- Sulfasalazine
- Sulfonylureas
- **Popular FACTSSS
- Patients with sulfa allergies may develop fever, urinary tract infections, pruritic rash, Stevens-Johnson syndrome, hemolytic anemia, thrombocytopenia, agranulocytosis, and urticaria (hives)
- Symptoms range from mild to life-threatening
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