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Designed to receive and transmit electrical and
chemical signals throughout the body
Nervous tissue
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Nervous (or neural) tissue is found in the
brain, spinal cord, and peripheral nerves
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Nervous (or neural) tissue is composed
primarily of two general cell types
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Name the 3 avenues of communication:
Circulation, Nervous and Lymphatics
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Neurons are the longest cells in the body and are composed of three primary parts:
- Perikaryon (stroma) – cell body
- Dendrites – short cytoplasm extension
- Axon – long single extension of cytoplasm
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________ receive impulses from the other cells,
________ conducts impulses away from the cell body
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Function of Neuroglial cells
- support the neurons.
- isolate the conductive membranes
- provide a supportive framework that helps to bind the components to neuronal tissue together
- phagocytize debris
- help supply nutrients to neurons by connecting them to blood vessels
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What systems maintain homeostasis.
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The nervous system has three basic functions:
- sensory functions (externally) pinch,
- integrating functions (within the spinal cord)
- motor functions (externally) goes back to the effector ograns
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Impulse that goes from the spinal cord back to the muscle is called a
simple reflex
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Section of the neuron that is large and contains the nucleus of the cell
cell body (soma, stroma or perikaryon)
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synthesize the materials needed by the neuron
(neurone), particularly energy (_______) and neurotransmitters (synthesized by the _______
and _____________)
- mitochondria
- ribosomes
- rough endoplasmic reticulum
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________ give the grey coloration to the areas of the spinal cord that contain the cell bodies of the neurons, the so-called _________.
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Extensions from the soma that receive stimuli, or impulses from other neurons and convey this stimulation to the cell body
Dendrites
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Extension from the soma and conducts the nervous impulse away from the perikaryon toward another neuron or other type of cell.
axon
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Axons are often covered in a fatty substance called
Myelin
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Nervous tissue containing many myelinated axons is often referred to as _________.
Nervous tissue without myelin = _________.
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Peripheral nerve covered in myelin is called
Schwann cell
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The axon may branch along its length producing _______ that allow the nervous impulse to be transmitted to more than one other cell
collaterals
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4 CNS neuroglial cells are:
astrocytes, oligodendrocytes, microglia cells, and ependymal cells.
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2 PNS neuroglial cells are
satellite cells and Schwann cells
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Functions of Astrocytes (CNS cells):
- 1. Responsible for the blood-brain barrier.
- 2. Stabilize the neurons from excessive movement and preventing damage to tissue.
- 3. Can change the composition of the interstitial fluid bathing the neurons
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Malignant tumor of astrocyte cells
Astrocytoma
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If a nerve has no myelin, the lining of the nerve is termed
If the nerve has myelin in the form of oligodendrocyte cells of the CNS or Schwann cells of the PNS, the outer lining of the myelin is then termed the ______ while the nerve lining is the ________.
- neuro or neurilemma
- neurolemma
- axolemma
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Function to wander through the CNS and with their phagocytic activity, engulf and destroy cellular waste products, debris and pathogens
Microglia (CNS cells)
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Line the ventricles of the brain and spinal canal. They are responsible for the circulation of cerebrospinal fluid that surrounds and protects the brain and spinal cord. They may also aid in its production and the monitoring of its composition
Ependymal cells (CNS cells)
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Located in the PNS with Schwann cells. These cells surround the clusters of cell bodies known as ganglia (singular = ganglion), insulating them from their surroundings. They are responsible for surging the impulse in a different direction
Satellite Cells (PNS cells)
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A space between the inner and middle of the
three layers of connective tissue which surround the brain
subarachnoid space
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The myelin sheath is actually the cell membrane of specialized glial cells called ________ in the brain and spinal cord and __________ in the nerves outside the brain and spinal cord.
- Oligodendrocytes
- Schwann cells
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Between adjacent glial cells are small gaps in
the myelin sheath called
Nodes of Ranvier
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_______ are fat cells
______ is tumor of fat cells in the spinal cord
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There is no anatomical method differentiating between axons and dendrites. All cell processes appear similar. Normally seen in the brain
Anaxonic neurons
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Have two processes arising from the cell body in the middle. Normally seen in the ear, eye, and nose
Bipolar
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Have a continuous dendritic and axonal process with the cell body lying of to one side. Generally have a long axon and in PNS. Example cranial nerves
Unipolar
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Have one axon from cell body with several dendrites coming in. Most common CNS. Prototypical neuron
Multipolar
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Sensory – of the PNS are _____ – they carry impulses from the sensory receptors toward or into the CNS
afferent
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Motor – of the PNS are _____ – they carry impulses from the CNS to peripheral tissues, organs or organ systems
efferent
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_______ Are those situated between sensory and motor neurons and are found only in the CNS. These are sometimes called ________.
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____________ neurons carry information from the external environment to the CNS
Somatic sensory
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__________ neurons carry information from within the animal (its organs and other systems) to the CNS
Visceral sensory
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Each axon is surrounded by a fibrous connective tissue called the ______ and that groups of these axons are held in bundles by connective tissue known as the ___________. These are further held together by an outer fibrous sheath called the _______which also encloses a blood supply and fat deposits
- endoneurium
- perineurium
- epineurium
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Axons with myelin sheath = __________.
Axon on axon itself referred to as _________.
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Study of the functioning of nervous tissue, i.e. how the neurons and glial cells transmit and process information
Neurophysiology
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Extracellular Fluid (ECF) has a high concentration of ___________ and _______
Intracellular Fluid (ICF) has a high concentration of _______ and ________.
- sodium ions (Na+) and chloride ions (Cl-)
- potassium ions (K+) and negatively charged proteins
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There is an overall excess of negative charge on the inner surface of the membrane when compared to the outer surface. This difference in electrical charge is called the _________ or _________ of the cell membrane
- transmembrane potential
- resting potential
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K+ moves out of the neuron and the Na+ moves into the neuron normally without the sodium/potassium pump in _________ through the K+ channels and Na+ channels;
It takes energy in the form of ________ to move the Na+ ions out for K+ ions that they move in.
Active transport is also known as
- Passive Transport
- Active Transport
- Passive diffusion.
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The transmembrane potential across the cell membrane is approximately –70mV in a resting neuron. This is also referred to as the _____ and the cell membrane can be said to be ____.
- resting potential
- polarized
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When the inside of the cell becomes positively charged and the outside negatively charged, for a short period of time. This process is known as ______ and the change in potential is called the ________.
- depolarization
- action potential
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The level of depolarization that is required before an action potential can be triggered is called the
Threshold
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The strength of the muscle contraction is dependent on
the number of muscle fibers stimulated
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Amount of energy needed to start to stimulate the nerve is called
threshold stimulus or Action potential
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If a second stimulus acts upon a neuron in which an action potential is ongoing, then a second action potential will not be produced. The neuron at this stage is unresponsive and is said to be in a
refractory stage
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The time that it takes for the neuron to be able to generate a second action potential from the start of the first is called the
absolute refractory period
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The period between the end of the absolute refractory period (when it is impossible to initiate another action potential) and a return to the resting potential is known as the
relative refractory period
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Transmission between one neuron and another neuron occurs at the
synapse
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Transmission between a neuron and muscle fiber occurs at the
neuromuscular junction
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At the synapse, the action potential from the axon of first nerve cell is carried across the interstitial space, known as the _______, to the dendrites of the next nerve cell
synaptic cleft
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Type of transmission that occurs when the two cells are very close together, as the synaptic gap or cleft is small. In some, but few cases, the membranes may be fused. In the cells that are very close together, the action potential is automatically propagated into the adjacent cell by causing a membrane depolarization, just as the action potential is propagated along the axon itself
Electrical
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Type of transmission when the synaptic gap is large, an impulse in the presynaptic neuron causes the release of a chemical into the gap
Chemical
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Peripheral Neurotransmitter classification:
- 1. Amino acids
- 2. Monamines (modified amino acids)
- 3. Polypeptides
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Four receptors of norepinehrine
alpha 1, alpha 2, beta 1, beta 2
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Inhibitor of acetylcholine
acetylcholinesterase
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2 Transmitters of the CNS
- 1. Gama- aminobutyric acid (GABA) - Inhibitory neurotransmitter of CNS. Binding GABA to its receptor produces hyperpolarization or inhibition. Blocks out external sounds.
- 2. Glutamate - Excitatory neurotransmitter of CNS. Receptors for Glutamate are involved with memory and learning
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Function of Cerebrospinal Fluid is to
- Protect the brain and spinal cord by forming a fluid cushion between the delicate nerve tissues and the bones of the skull and vertebral column
- Maintains constant pressure within the skull
- Carries waste and toxic substances away from the tissue to the interstitial fluid of the CNS
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Infection of the brain
Encephalitis
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Infection of the spinal cord and brain
Encephalomyelitis
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Infection of the spinal cord
Meningitis AKA Myelitis
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The three layers of connective tissue which surround the brain are known as the ________ and consist of
- meninges
- Pia mater – lies on the surface of the spinal cord
- Arachnoid mater – separated from the pia mater by the subarachnoid space via CSF
- Dura mater – is the outer layer and is a thick membrane composed of tough fibrous tissue that lines the inside of the skull forming the periosteum
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Samples taken by the veterinarian may be collected for analysis from an enlargement of the subarachnoid space at the base of the skull called the
cisterna magna
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Both the ___ and _______ are also responsible for the basic control of heart rate and respiration, known as the _______. The third area, the _______ controls the motor coordination of the body
- pons and medulla
- brainstem reflexes
- CEREBELLUM
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The spinal cord runs within the protective vertebral column from the ___________, terminating at the ____________.
- cisterna magna
- cauda equina
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How many spinal nerves leave the spinal cord, passing through the intervertebral foramina, each passing to a different part of the body
Thirty six pairs
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Efferent Nerves can be divided into two broad categories
- 1. those which are part of the PNS-Somatic Nerves, supply skeletal muscle
- 2. And those PNS - supplying smooth muscle, cardiac muscle, and glands from the Autonomic System (AS).
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Somatic Nerves carry impulses from the CNS to skeletal muscles
Efferent Nerves of the PNS-
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Which Cranial Sensory nerve carries the sense of smell impulses to the brain.
Olfactory
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Cranial Motor – carry impulses from the brain to
the effector organ muscles of the eye.
Trochlear
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Cranial Mixed - carry impulses from the brain to the effector organ and back to the brain.
Motor jaw movement sensory from skin to the facial region
Trigeminal
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Nerves that supply the entire musculoskeletal system
Spinal
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Optic
Type of nerve
Function
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Oculomotor
Type of nerve
Function
- Motor
- Eye movement, pupil size, focusing lens
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Trochlear
Type of nerve
Function
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Trigeminal
Type of nerve
Function
- Mixed
- Movement of jaw muscles; sensory from facial region
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Abducent
Type of nerve
Function
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Facial
Type of nerve
Function
- Mixed
- Muscles of facial expression; Muscles of the tongue
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Auditory
Type of nerve
Function
- Sensory
- Balance and hearing
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Glossopharyngeal
Type of nerve
Function
- Mixed
- Motor to the pharynx; Sensory – taste from tongue
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Vagus
Type of nerve
Function
- Mixed
- Supplies the larynx, thoracic and abdominal viscera including, digestive tract, controlling its movements and secretions
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Accessory
Type of nerve
Function
- Motor
- Movement of neck, pharynx and soft palate
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Hypoglossal
Type of nerve
Function
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Network of nerve fibers that gives rise to the radial, ulnar, and medial nerves supplying the forelimb
brachial plexus
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Network of nerve fibers that gives rise to the sciatic, obturator, perineal, pudendal, and others
pelvic plexus
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Suprascapular innervates with what muscles
supraspinatus and infraspinatus
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Pectorals innervates with what muscles
- Descending superficial pectoralis
- Transverse superficial pectoralis
- Deep pectoral
- Xiphihumeralis
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Musculocutaneous innervates with what muscles
biceps brachii and brachialis
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Axillary innervates with what muscles
teres minor and deltoids
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Radial innervates with what muscles
triceps brachii, anconeus, and extensors distal to the elbow
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Ulnar innervates with what muscles
Flexors distal to the elbow
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Median innervates with what muscles
Flexors distal to the elbow not covered by ulnar
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Thoracodorsal innervates with what muscles
Latissimus dorsi (draws the limb caudally)
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Lateral thoracic innervates with what muscles
Cutaneous trunci
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Cranial Gluteal innervates with what muscles
Middle and deep gluteal and tensor fasciae latae
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Caudal Gluteal innervates with what muscles
Superficial gluteal, semitendinosus, biceps femoris (only in horse)
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Femoral innervates with what muscles
Sartorius, quadriceps femoris
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Obturator innervates with what muscles
adductors, gracilis, pectineus, obturator externus
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Sciatic innervates with what muscles
Semimembranosus, biceps femoris, obturator internus, gemelli, quadratus femoris
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Peroneal innervates with what muscles
Tibialis cranialis, long digital extensor, peroneus
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Tibial innervates with what muscles
Gastrocnemius, superficial digital flexor, tibialis caudalis, popliteus
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Pavlov proved that a dog would salivate when food is placed in the mouth, and as such is an inborn involuntary action, known as a _____. Later Pavlov would associate the bell ringing with food and before long dogs would salivate when they heard the bell only. This type of
response is called a ________.
- reflex response
- Conditioned Reflex Response
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8 Reflexes for Surgical Monitoring
Anesthetic depth can be indicated by the utilization of basic reflexes.
- 1. Palpebral (blink reflex) – Qtip in eye – eyelid will quiver
- 2. Pedal – pinch toe – animal pulls leg back
- 3. Ear flick – rub hair inside pinnae – ear quivers
- 4. Corneal – Qtip on cornea – cornea quivers
- 5. Size of Pupil – dilation of pupil
- 6. Pupillary Light – shine light in eye – both eyes should constrict – consensual light reflex
- 7. Heart and Respiratory – always going to be suppressed.
- 8. Response to Surgical Stimuli – Cut on an animal and it moves
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2 forms of the afferent system of the PNS.
- 1. Somatic sensory neurons
- 2. Visceral sensory neurons
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Provide information about the external environment of the animal.
Somatic Sensory Neurons
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Monitor the internal environment and organs
Visceral Sensory Neurons
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Classification of Receptors - Where they receive their stimulus:
1 These are stimulated by information from the external environment such as touch, sight, smell, hearing, taste, pressure and temperature.
2. These monitor movements and position of the skeletal muscles and joints.
3. These monitor the internal environment such as the respiratory, digestive, urinary,
cardiovascular and reproductive systems. They are also stimulated by deep pressure and pain.
- Exteroceptors
- Proprioceptors
- Interoceptors
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Structure of the Receptors
___________ are involved in detecting touch and painful stimuli are located in the skin, muscles, and viscera. Nerve endings in the cornea are also stimulated by touch pressure and temperature
Unspecialized free nerve endings
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Structure of the Receptors
________ or __________, are located in the dermis of the skin and respond to touch and pressure
Specialized or encapsulated nerve endings
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Structure of the Receptors
__________ receptor cells which are located in the ear and eye , as well as the taste buds
Specialized non-neuronal
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Detect chemical changes in the local area around the receptor. Example the ones in the brain detect changes in oxygen and carbon dioxide in blood as well as osmoreceptors detect changes in salt concentrations
Chemoreceptors
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Responds to touch and pressure and are predominantly located in the skin. There are also receptors that detect the degree of stretch of muscles in the stomach, lungs and blood vessels
Mechanoreceptors
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Are stimulated by changes in temperature and are located in the skin
Thermoreceptors
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Usually triggered by any stimulus that may cause tissue damage or injury. Release of chemicals in an area of inflammation may also trigger these receptors
Pain receptors or nociceptors
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Are stimulated by light and are found in the retina of the eye.
Electromagnetic receptors
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Are a collective term used to group together all the receptors that relay information about the position of the body and its movements.
Proprioceptors
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The postganglionic sympathetic neurons with which they synapse are located in three different locations:
- a. sympathetic chain ganglia or lateral ganglia
- b. collateral ganglia
- c. adrenal medulla
-
Sympathetic Chain Ganglia
Stimulation causes:
- constriction of blood vessels in the skin
- increase blood to skeletal muscles and brain,
- release of lipid from fat stores,
- dilation of pupils
- acceleration of heart rate and strength of cardiac contraction, and
- bronchodilation
-
Collateral Ganglia
Stimulation causes:
- reduced blood flow to visceral organs
- decreased activity of digestive system
- release of glucose from glycogen reserves in the liver
- reduction in the rate of formation of urine
- stimulation of release of lipids from fat stores
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Adrenal Medulla - neurotransmitters release directly into the blood stream. This mechanism allows the neurotransmitters, _______ (________) and _______ (________) to have an effect as hormones on many target cells throughout the body
- epinephrine (adrenaline)
- norepinephrine (noradrenaline)
-
Pharmaceuticals that produce sympathetic responses are referred to as being
adrenergic
-
norepinephrine effects ________
epinephrine effects ___________
-
List the receptors that are involved with shock:
- Alpha 1 – constrict blood vessels and allows the blood to be diverted to areas that need the blood like the heart
- Beta 1 – acts on cardiac muscle to increase cardiac output by speeding up the impulse and force of the contraction.
- Beta 2 – acts on smooth muscle to relax smooth muscles of airways to ease breathing and allow for increase of absorption of oxygen
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Major nerve that carries information from most of the parasympathetic division is called the __________ and supplies all the organs and structures within the thorax and abdomen.
Vagus Nerve (X)
-
Not all organs have dual innervation. List 3 examples
- The spleen and adrenal medullae have only sympathetic innervation
- The ciliary muscles of the eye are only innervated by the parasympathetic system thus causing a constriction.
-
A base level of activity that can increase or decrease, depending upon the situation
State of tone
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The parasympathetic system exerts a basal tone on the activity of the _____ via the ______.
-
More complex processes require the use of higher levels in the brain and are coordinated within the
medulla oblongata
-
The medulla and pons are regulated by the
hypothalamus
-
Cranial nerves that control respiration and pulse are
IX Glossopharyngeal and X Vagus
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