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Objective:
Describe the location and general features of the heart. (pp.437)
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Blood flows through a network of _____ ______ that extend between the heart and peripheral tissues
Blood vessels
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Two divisions of blood vessels circuits
- Pulmonary Circuit
- Systemic Circuit
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Pulmonary Circut
carries blood to/from the exchange surfaces of lungs
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Systemic Circuit
transports blood to/from the rest of the body
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Blood travels through the circuits in
sequence, meaning blood returning to the heart from the systemic system must complete the pulmonary circuit before re-entering the systemic circuit
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Arteries
Efferent vessels, carry blood away from the heart
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Veins
Afferent vessels, return blood to the heart
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Capillaries
- are small, thin walled vessels between the smallest arteries and the smallest veins
- Thin walls permit exchange of nutrients,dissolved gases and waste products.
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Heart is the size of a
Clenched fist
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The heart contains two chambers associated with each circuit
Atrium/Ventricle for each
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Right Atrium
receives blood from the systemic circuit
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Left Atrium
collects blood from the pulmonary circuit
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Right Ventricle
dischages blood into the pulmonary circuit
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Left Ventricle
Ejects blood into the systemic circuit
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When the heart beats, what is the order of contraction
Atria then ventricles
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Objective: Identify the layers of the hearts wall.(pp. 438-441)
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The heart lies anterior wall: Deep to the
sternum
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The connective tissue mass that divides the thoracic cavity into the pericardial cavity/ two plural cavities and contains the thymus,esophagus , and trachea is?
The mediastinum
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The heart is surrounded by the _________ cavity
Pericardial caivty
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The lining of the pericaridal cavity is
the serious membrane called the pericardium
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Pericardium subdivisions
- Visceral(epicardium)
- Pericardial cavity
- Pericardial Sac
- Parietal
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Visceral Pericarium
- Epicardium
- covers the surface of the heart
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Pericardial cavity
- normally contains a small quantity of pericardial fluid secreated by the pericardial membranes
- acts as lubiricant and reduces friction between opposing surfaces as the heart beats
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Pericardial sac
dense network of collagen fibers taht stabilizes the positions of the pericardium,heart and associated vessels in the mediastinum
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Atria are relatively thin muscular walls that are highly
expandable
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When the atrium is not filled with blood, its outer portion deflates into a lumpy wrinkled flap called
an auricle
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Coronary sulcus is a deep grove with substantial amounts of fat that mark the border between....
artia and ventricles
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The two shallower depressions that mark the boundry between the left and right ventricles are
Anterior/Posterior interventricular sulcus
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Apex of the heart is
the inferior pointed tip
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Three layers of the heart wall
- Epicardium(visceral pericardium)
- myocardium
- endocardium
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Epicardium
- Covers the outer surface of the heart
- layer contains exposed epithelium and underlying layer of loose connective tissue that is attached to the myocardium
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myocardium
- muscular wall of the heart
- contains cardiac muscle tissue,blood vessels, and nerves.
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Cardiac muscle tissue of the myocardium forms concentric layers that wrap around...
- around the artia and spiral into the walls of the ventricles
- this arrangement allows twisting contractions that increase pumping effenciency of the heart
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the hearts inner surface is covered by the
endocardium
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Endocardium is what type of epithelium?
Simple squamous, that is continuous with the endothelium of the attached blood vessels
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Traits of cardiac muscle cells
- smaller then skeletal muscle cells
- single centrally located nucleus
- contain myofibrils
- contraction of individual sarcomeres
- almost totally dependent on aerobic metabolism
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Intercalated discs
interlocking membranes of adjacent cells held together by desmosomes and linked by gap junctions.
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desmosomes help
convey the froce of contraction from cell to cell and efficiency as they "pull together" during a contraction
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gap junction allows movement of
ions and small molecules and enables action potential to travel rapidly from cell to cell
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Collagen and elastic fibers provide...
- support for cardiac muscle fibers,blood vessels, and nerves of the myocardium
- add strength and prevent overexpansion of the heart
- help the heart return to normal shape after contractions.
- forms the fibrous skeleton of the heart
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Objective: Trace the flow of blood through the heart, identifying the major blood vessels,chambers, and heart valves(pp. 442-446)
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Two artia are separted by the
interatrial septum
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Two ventricles are separated by the
inventricular septum
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Each atrium opens into the ventricle through an
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Right artium receives blood from the superior and inferior
Vena cava
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cardiac veins of the heart return venous blood to the
coronary sinus which opens into the right atrium slightly below the connection with the inferior vena cava
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fossa ovalis
- small depression where an oval opeing- the foramen ovale penetrated the interatrial steptum from the 5th week of embryonic development until birth
- allowed blood to flow free fro, right to left atrium while lungs are being developed
- after 48 hours from birth it is sealed
- if remains open after birth leads to cardiac hypertrophy and possible death
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Blood from the right atrium to right ventricle travels through three flaps of fibrous tissue called
Cusps and are part of the right AV valve AKA tricuspid valve
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Each cusp is embraced by connective tissue fibers called
chordae tendineae
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Chordae tendineae are connected to papillary muscles which are
cone shaped projections on the inner surface of the entricle.
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Contraction of the papillary muscles tenses the
chordae tendineae, limiting the movement of the cusps preventing backflow of blood
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blood leaving right ventricle flows into the
pulmonary trunk, which starts pulmonary circuit
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What valve gaurds the entrance of the pulmonary trunk?
pulmonary semi lunar valve
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Pulmonary trunk to left and right pulmonary arteries ,which branch repeatedly in
the lungs before supplying cappillaries
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Respirtatory capillaries oxygenates then moves into the let and right
pulmonary veins
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pulmonary veins to
the left atrium
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left av valve or
bicuspid cotains two pairs not three, aka Mitral valve
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left ventricle to the aorta through the
Aortic semi lunar valve, then starts systemic circuit
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Right ventricle
- due to the proximity of the lungs, it does not have to push very hard to propel blood through the pulmonary circuit
- pulmonary blood vessels are relatively short and wide
- wall of right ventricle is relatively thin
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Left ventricle
- thick walls
- requires 6-7 times more force to propel through the systemic circuit
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When the left ventricle contracts two things happen
- distance of between the base and apex decrease
- diameter of ventricular chamber decreases.
- twising like
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Av valves prevent
blood backflow from the ventricle into the artia
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Ventricle relaxed=
Chordae tendinae lose and Av offers no resistance
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Ventricles contract=
tension in the papillary muscles and chordae tendineae keeps the cusps from swininging into the artium
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swirling blood blood creates a soft but distinctive sound called
heart murmur
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Pulmonary/ aortic semilunar valves prevent backflow from the
pulmonary trunk and aorta into the right and left ventricles respectively.
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Due to arterial walls not contracting and stable position of cusps the, semi lunar valves do not require
muscular bracing as the AV do
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Aortic sinuses
prevent cusps from sticking to the wall of the aorta when the valve opens, they are sac like expansions at the base of aortic and next to each cusp of the aortic semilunar valve
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The left and right coronary arteries origionate at the
aortic sinuses
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Fibrous skeleton
consists of dense bands of elastic connective tissue that encrircle the bases of large blood vessels that carry blood away from the heart and each heart valve
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position of the heart valves and isolation of the artial muscule tissue from ventricular tissue is done by
the fibrous skeleton
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What supplies blood to the muscle tissue of the heart?
Coronary circulation
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Left and right coronary arteries origionate
at the base of the aorta at the aortic sinuses
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RCA
supplies blood to the right atrium and portions of both ventricles
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LCA
supplies blood to the left ventricle, left atrium,and intraventricular septum
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Each coronary artery has two branches:
branches for RCA
marginal and posterior interventricular (descending) branches
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Each coronary artery has two branches:
branches for LCA
- circumflex
- anterior (descending) branches
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Small tributaries that from the branches of the LCA and RCAform interconennections called
anastomoses
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Veins of the heart are called
- the great and middle cardiac veins
- carry blood away from coronary capillaries and drain into the coronary sinus
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coronary sinus is located
posterior portion of the coronary sulcus.
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Coronary sinus opens into the
right atrium near the base of the inferior vena cava
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Objective:Describe the differences in action potentials and twitch contractions of skeletal muscle fibers and cardiac muscle cells.(pp.450-451)
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Heartbeat
Entire heat, atria/ventricles contract in coordinated manner
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Two types of Cardiac muscles cells
- Contractile
- specialzied noncontractile muscle cells of the conducting system
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Contractile cells
99% all cardiac muscle cells
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In Cardiac/skeletal muscle cells, Action potential leads to Ca2+ in the myofibrils and binds to triponin on thin filaments begins contraction. What is the major difference between skeletal and cardiac concerning this
Duration of Action Potential, source of Ca2+, duration of contraction
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An action potential in ventricular cardiac muscle begins when
the membrane is brought to threshold by stimulus (typically excitation of adjacent muscle cells)
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Action potential of cardiac cells steps 1
- Rapid depolarization, at threshold, voltage-regulated sodium channels open
- Influx of Na+ ions rapidly depolarizes the sarcolemma (cell membrane)
- Sodium channels close when the transmembrane potential reaches +30mV
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Action potential of cardiac cells steps 2
- The plateau
- as Na+ is actively pumped out ,voltate regulated Ca2+ channels open and extracellular Ca2+ ions enter the sarcoplasm.
- Ca2+ channels remain open for relatively long period roughly balance the loss of Na+ from the cell.
- Extracellular Ca2+ delay repolarization (positive charges maintain a transmembrane potential near 0mV(the plateau) and initiate contraction
- increased contraction within the cell triggers release of Ca2+ from reserves in the SR,which continues contration
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Action potential of cardiac cells steps 3
- Repolarization
- As calcium channels begin to close, K+ channels open, and K+ ions rush out of the cell. This restores the resting potential.
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Depolarization of cardiac muscle is how many times longer then skeletal muscle?
25-30 times
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In cardiac muscle the refractory period continues till
relaxation is under way
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Automaticity
- Autorhythmicity
- Cardiac tissue contracts on its own in the absence of neural or hormonal stimulation
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Cardiac contractions are coordinated by the hearts
- conducting system
- a network of specialized cardiac muscles cells that initiates and distributes electrical impulses
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Conducting system is made of two types of cardiac muscles that do not contract
- Nodal cells
- Conducting cells
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Nodal cells
responsible for establishing the rate of cardiac contration and located at the sinoatrial (SA) and atrioventricular (AV) nodes
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Conducting cells
- which distribute the contractile stimulus to the general myocardium
- AV bundle
- bundle branches
- Purkinje fibers
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Nodel cells depolarize how?
spontaneously and generate action potentials at regular intervals
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Nodal cells are electrically coupled...
- to one another, to conducting cells and normal cardiac cells
- as a result when an AP is initiated in a nodal cell, it sweeps through conducting system, reaching all cardiac muscle tissue and causing a coordinated contraction
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Normal rate of contraction is established by
the pacemaker cells
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SA node
- sinoatrial node
- tissue mass embedded in the posterior wall of the right atrium, near the enterance of the superior vena cava
- 70-80 depolarizes bpm
- AP travels to AV node
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AV node
- conduct cells in atrial wall
- 40-60 spontaneously
- if AP from SA is not sent
- located in the floor of the right atrium
- AP travels to bundle of his
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AV bundle (bundle of his)
- conducts along intraventricular septum then divides into the left and right bundle branches radiate across the inner surface of the left and right ventricles
- Then purkinje fibers convey electrical impulses to the contractile cells of the ventricular myocardium.
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Etopic pacemaker
rouge ventricular muscle cell or abnormal conducting cell may begin generating AP and overiding the SA or AV
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P wave
Depolarization of Atria
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QRS
- Ventricular depolarization
- Ventricles contract shortly after the peak of the R wave.
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T wave
represents repolarization of ventricles
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Objective: Explain the events of the cardiac cycle and relate the heart sounds to the specific events of the cycle. (pp.457-458)
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The period between one heart beat and the start of the next is called
A single cardiac cycle
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Cardiac cycle contains
a period of contraction and of relaxation
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During contraction (systole)
the chambers squeezes blood into an adjacent chamber or into an atrial trunk.
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Relaxation (diastole)
when the chamber fills with blood and prepares for the next cardiac cycle.
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Pressure in each chamber rises and falls when?
- rises in systole
- falls in diastole
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Cardiac cycle in order
- atrial systole-atrial diastole
- ventricular systole-ventricular diastole
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Phases Cardiac cycle 1
- Atrial systole beings
- atrial contraction forces blood into relaxed ventricles
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Phases Cardiac cycle 2
Atrial systole ends: atrial diastole begins
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Phases Cardiac cycle 3
- Ventricular systole 1
- ventricular contraction pushes the av valves close but does not create enough pressure to open semilunar valves
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Phases Cardiac cycle 4
- ventricular systole 2
- ventricular pressure rises and exceeds pressure in the arteries
- semilunar valves open and blood is ejected
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Phases Cardiac cycle 5
- ventricular diastole early
- as ventricles relax; ventricle pressure drops and blood flows back against cusps of semilunar valves and forces them closed
- blood flows into relaxed artia
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Phases Cardiac cycle 6
- Ventricle diastole
- all chambers are relaxed ventricles fill passively
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Objective:
Define stroke volume and cardiac output and describe the factors that influence each. (pp.458-462)
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Heart dynamics
movements and forces generated during cardiac contractions
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Stroke Volume (SV)
The amount ejected by a ventricle in a single beat
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Cardiac output (CO)
Ammount of blood pumped by each ventricle in one minute
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Cardiac output formula
SVxHR=CO
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Factors that control cardiac output
- blood volume reflexes
- autonomic innervation
- hormones
- concentration of extracellular ions
- temperature
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atrial reflex(bainbridge reflex)
produces adjustments in heart rate as a response to increase in venous return,
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The ammount of blood pumped out of a ventricle each heart beat depends on venous return and
filling time
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ANS response to heart rate
response of SA node to ACh and NE
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ACh released by Parasympathetic motor neurons
lowers heart rate
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Cardioaccelerory center
activates sympathetic motor neurons
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Cardioinhibitatory center
controls parasympathetic motor neurons
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Cardiac centers respond to changes in blood pressure and
- changes in the arterial concentrations of dissolved gasses O2 and Co2
- Monitered by barorenceptors and chemoreceptors innervated by the NIX glassopharyngeal and X vagus nerve
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