Pralidoxime

Cholinesterase Reactivator , (2 PAM)

Reactivates the cholinesterase inhibited by phosphate esters by displacing the enzyme from its receptor sites. This restores the normal functions of the neuromuscular transmission.

An antidote and treatment for organophosphate poisoning

• Severe Cardiac Disease
• Peptic Ulcer
• Asthma
• MI
• Hypersensitivity to Procainamide / Procaine

• Tachycardia
• Hypertension
• Dizziness

1-2 grams in 250-500ml of NS infused over 15-30 mins ; if no IV access is available 1-2 grams IM / SC