-
Oral Meds are absorbed through the ____, whereas injected meds are absorbed through the ___,____,_____, or _____
- Mucosal lining of the GI tract
- Blood vessels, Muscles, Subcutaneous Tissue, or Dermal Layers
-
When meds are injected _____, no absorption is needed
Directly into a vein or artery
-
Drugs travel through the circulatory system to its receptor site and then connect with the molecular structure for which it was designed for, this is called
Distribution
-
Which process depends on adequate circulation?
Distribution
-
Drugs act more quickly in organs with an abundant blood supply like,
liver, heart brain, kidneys
-
Most metabolism happens in the _____, where enzymatic action transforms a drug into ____ that can excreted via intestines or kidneys
-
What are the chief organs of excretion?
Kidneys
-
If kidney function is impaired or if the patient is dehydrated, drugs can be retained in the body and a ____ effect can occur
toxic
-
Generic names identify the
substance
-
___or___ are given by the manufacturer
Proprietary or trade names
-
____ is a substance that alters physiologic function, with the potential to affect health
drug
-
____ is a drug administered for its therapeutic effects
Medication
-
Science of drugs, including sources, chemistry, and actions of drugs is
Pharmacology
-
Each drug has 4 separate names
- chemical
- generic
- official
- brand
-
Resources for drugs are
- #1 PDR physician's desk reference
- USP- United States pharmacopia
- Specific drug pkg
-
What is the way in which drugs affect the body
Pharmacodynamics
-
Each drug has a unique ____enabling it to interact with a specific enzyme or a corresponding cell type
Molecular structure
-
The drug attaches itself to a target site in the body called a
receptor site
-
The combined effect alters the behavior of the targeted cells and causes ____ changes in the patient
physiologic
-
What is a way that drugs travel through the body to their appropriate receptor sites
Pharmacokinetics
-
Most of the time, the drugs travel in ____
the blood stream
-
Every drug must be ____ in the blood stream to be effective
absorbed
-
Dosage and speed of absorption depends on factors such as
- route of entry
- ph of recipients enviroment
- solubility of formula
- drug's interaction with body's chemicals
-
Some drugs need to combine with ____ or ____
Proteins or cross membranes
-
____ is the process by which the body alters the chemical composition of a substance
metabolism
-
The ___ detoxifies foreign substances entering the body and changes them into a water soluble substance that can excreted by the ____
-
____ is when the body excretes drugs and their by-products through the what 7 things
- Excretion
- kidneys
- lungs (gases)
- sweat glands
- tear ducts
- salivary glands
- intestines
- mammary glands
- kids like sugary tea soaked in mustard
-
Rate of excretion depends on
- the body's systems
- the drug's 1/2 life
- concentration of tissues
-
Patient related variables for doses are what 5 things
- age
- weight
- physical condition
- gender
- person and emotional requirements
-
Younger children require ____ of a dose and ____ is used for calculation
-
Older patients require ____ because decrease in efficiency of organs and slowing of circulation. ___ and ____ become imparied
-
Average dose is based on ____ adults
healthy 150lb
-
Women have a lower average body weight than men and ____ drugs differently
metabolize
-
Women's ___ and the amt and distribution of ___ and the difference in ___ alter the metabolism
- hormones
- body fat (since we have more)
- body fluid
-
____ can alter the way a patient reacts to drugs, positive and negatively.
Patient expectations
-
Drug related variables (9)
- Side effects
- complications
- allergic reactions
- tolerance
- cumulative effect
- idiosyncratic effects
- dependence
- drug interactions
- iatrogenic disease
- (Some Complications Are Too Crazy In Drug Dependence Incidences)
-
____ are expected reactions to medication
side effects
-
____ are unexpected and can range from mild to severe
Complications
-
In allergic reactions, the drug acts as an ____ and the body develops ____ to that drug
-
AN allergic reaction can range from
light rash to anaphylactic shock
-
____ is when a body adapts to a drug and requires greater doses to achieve the desired effect
tolerance
-
____ develops if the body is unable to detoxify and unable to excrete a drug quickly enough or if too large a dose is taken. the drugs then accumulate in the ____ and become ____
- Cumulative effect
- tissue
- toxic
-
____ is inexplicable and unpredicted symptoms caused by a genetic defect in the patient
idiosyncratic effect
-
____ is when you have had extensive exposure to the drug
dependence
-
_____ occurs when 2 or more drugs or a combo of food and drugs can create + and - effects
drug interactions
-
___ results from long term use of a drug that damages organs or causes other disorders over time
Iatrogenic disease
-
____ are the 6 rights of administering medications
- Identify right patient
- Select the right medication
- Give the right dose
- Give the right med at the right time
- Give the med via right route
- Ensure right documentation
-
Therapists should know ___ of emergency supplies and the way to administer ____ and ____
-
Examples of emergency situations are
- Asthma attack
- Pulmonary edema
- Anaphylactic shock
- Cardiac Arrest
-
In case of emergency what would a therapist do
1 therapist calls 911 while the other gets the doc
-
what do Analgesics do
relieve pain
-
____ suppresses sensation of feeling
anesthetics
-
____ is a mild tranquilizer that helps calm anxious pts and relieves muscle spasms
Anti anxiety
-
____ suppresses growth of bacteria
antibiotic
-
___ prevents blood from clotting
anticoagulants
-
____ inhibit or control seizures
anitconvulsants
-
____ are mood controllers
antidepressants
-
____ control GI distress
Antidiarrheal
-
____ prevent nausea and vomiting
anitemetic
-
____ treat fungal infections
antifungal
-
____ treats allergies
antihistamine
-
____ lower blood pressure
antihypertensive
-
____ is chemotherapy
Antineoplastic
-
____ enhances internal tissues for diagnostic imaging
contrast media
-
Examples of contrast media
Barium via oral, IV, paste, etc
-
____ reduces inflammation
antiinflammatory and corticosteroids
-
___ remove fluid from cells
diuretics
-
_____ used to augment (increase) endocrine secretions
hormones
-
_____ relieves pain
narcotics
-
____ is used in nuclear medicine exams
radioactive isotopes
-
____ induce sleep or unconsciousness
sedatives
-
what are the 2 categories of contrast media
- Positive- radiopaque
- Negative- radiolucent
-
____ will appear white on xrays
- positive radiopaque
- (absorbs the xray)
-
What will appear dark on xrays
- negative- radiolucent
- (no absorption)
-
The higher the ____ the more absorption, like bone
atomic #
-
____ is the commonly used contrast agent in the GI tract. ____ is used in the esophagus
- Barium sulfate (heavy metal salt)
- paste
-
Barium can be delivered ___ or ____ and can cause ___ and ____ but cannot be used if
- orally or rectally
- cramping and constipation
- perforation of colon
-
_____are iodide atoms that attach to water-soluble carrier molecules and dispatch to areas of the body. the atoms displace ___in the cells and ___ xray protons in those regions
- organic iodides
- water
- absorb
-
_____ - the atoms splits into a + and - charged particle when it comes in contact with body fluids. With so many particles in the blood stream absorbing water, the ____ is affected
- Ionic contract
- body's fluid balance
-
_____- the atoms do not split therefore not causing as many problems with patients
nonionic contrast
-
____ is used in CT and MRI to inject the patient with contrast
power injector
-
The contrast media is quickly absorbed and metabolized by the ____
kidneys
-
What are minor reactions to contrast
- nausea
- retching
- mild vomitting
-
What are moderate reactions to contrast
- fainting
- chest and abdominal pain
- headaches
- chills
- severe vomitting
- edema of the face
-
What are severe reactions to contrast
- syncope
- convulsions
- pulmonary edema
- cardiac arrest
-
____ taken by mouth and slowly absorbed into blood stream
oral
-
Taking medicine via ____, are less potent but longer lasting than injected meds
oral
-
Suppository, inhalation of a medication mist, gargling, or dissolved under the tongue are examples of
Mucous Membrane drug administration
-
____ is when transdermal patches are applied directly to the skin
topical
-
_____ is drug administration by injection
parenternal
-
_____ is an injection between the layers of the skin
intradermal (like TB)
-
____ is a 45-90 degree into the subcutaneous layer just below the skin
Subcutaneous
-
_____ is a 90 degree injection into the muscle
intramuscular
-
____is an injection directly into the blood stream
intravenous
-
_____ is injected directly into the spinal cord
intrathecal
-
____ is injected directly into the trachea
intratracheal
-
____ is an injection directly into the brain
intracranial
-
Needles are measured by gauge, the smaller the gauge, the ____ the diameter of the needle
- larger
- (a 24 gauge is smaller than a 12 gauge)
-
What are the 3 methods of IV delivery
- Continuous infusion
- piggy backed
- bolus or push
-
IV solution should be 18-20" ___ the level of the vein
Above
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
SQ/SC
subcutaneous (subcue)
-
-
____ is when the vein cannot absorb the fluid quick enough and there is leakage around the injection site
infiltration
-
____ contrast media is injected into the tissue of the vein
extravasation
-
____ can be caused from electrolyte imbalance, edema, speed shock from too fast delivery, drug incompatibility, clotting, and phlebitis
Air embolism
-
What should be on an emergency crash cart
- Stethoscope
- BP cuff
- bag valve mask
- endotracheal tubes
- suction catheters
- sterile gloves
- cardiac monitor
- needles
- hemostat
- adrenalin
- atropine
- gulcagon
- nitro
- xylocain
-
Can you remove something from the crash cart for routine use
NO never
-
____ is placement of any tube. It is most commonly placed in ___
-
____ is the surgical opening through the anterior of the neck into the trachea
tracheostomy
-
____ is the mechanical respirator device powered by compressed air that controls the respiratory rate, volume, and o2 contrast
ventilator
-
O2 is usually delivered ___ per min
1-6 liters
-
___ occurs when the heart and rep function stop functioning. It ___ reversible
-
___ occurs 2-4 min after clinical death and ___ reversible. major brain and organ damage
-
____ difficulty breathing caused by bronchospasm
asthma
-
Signs of respiratory distress include
- Complaining of difficulty in breathing
- tachypnea
- abnormal breathing sounds
- cyanosis
-
____ is insufficient blood supply to the heart muscle that results from coronary disease
Myocardial Ischemia
-
____ is a heart attack. Cardiac arteries become occluded and a portion of the heart wall becomes ischemic
Myocardial Infarction
-
____ are when coronary arteries are unable to supply the heart muscle with sufficient O2
Angina pectoris
-
____ is a machine that administers electric shock to correct an ineffectual cardiac rhythm
defibrillator machine
-
What is an AED
automatic external defibrillator
-
___ is the general term used to describe a failure of ciruculation in which BP is inadequate to support O2 perfusion of vital tissues and is unable to remove them by products of ____
-
What are the 4 types of shock
- hypovolemic
- septic
- neurogenic failure
- cardiogenic
-
____ is when large amts of blood or plasma are lost (hemorrhage)
hypovolemic
-
____ is a massive infection that produces toxins that increase capillary permeability and drops BP quickly
Septic
-
____ is a failure of arterial resistance, causing blood pooling in the peripheral vessels
neurogenic failure shock
-
____ is cardiac failure
Cardiogenic sock (PE)
-
___ is when a pt is exposed to substance to which they are sensitive
Allergic reaction or anaphylaxis
-
What are the symptoms of an allergic reaction or anaphylaxis
- diff breathing
- swollen/tingling lips
- vomitting
- drop in bp
- metallic taste in mouth
- itching skin
- hives
- dizzy
-
____ is a very mild form of shock that occurs with fright, pain or an unpleasant event.
Syncope
-
Shock symptoms
- Restlessness/Apprehension
- Increased pulse
- Pallor with weakness or changes in thinking ability
- Cool clammy skin (except in neurogenic or septic)
- Fall in bp of 30mm below baseline systolic
- Decreased urination
- Increased and shallow respirations
-
-
____ is induced by problems with the kidneys or the pituitary that cause glucose to be excreted in the urine while blood glucose levels remain normal
Diabetes Insipidus
-
Symptoms for diabetes insipidus are
polyuria and thirst
-
____ (hyperglycemia) is the inability to metabolize blood glucose
Diabetes mellitus
-
Insulin is produced in the ___ in response to food intake
pancreas
-
insufficient insulin prevents the use of glucose by the ____. In response, the body wall break down fat or muscle causing ____ to build up in body
-
Symptoms of diabetes mellitus
- Fruity breath
- thirsty
- frequent urination
-
___ occurs when pts take insulin but no food. Blood sugar become low.
hypoglycemia
-
Symptoms of hypoglycemia
- weakness
- sweating
- tremors
- hunger
- loss of consciousness
-
If a hypoglycemic pt has an episode and they are conscious, you should ____, but if they are unconscious you can ___
- give candy or juice
- give an IV of dextrose solution
-
____ is a term for interruption of blood supply to the brain
- CVA
- cerebrovascular accident of stroke
-
What can cause a CVA
- hemorrhage
- occluded artery
-
A CVA can be ___ to ____
mild (transient ischemic attack) to major
-
Warning signs for a CVA
- slurred/difficulty in speech
- extreme dizziness
- severe headache
- muscle weakness
- vision problems
- temporary loss of consciousness
-
If someone is suffering from a CVA, you should
lay them supine with head elevated and call for emergency help
-
___ is local or generalized brain function or disturbance
seizure
-
If a pt is having this type of siezure, do not restrain them, but keep items that can injure them away and if they are on the table, just keep the from falling
Tonic-clonic seizure (grand mal)
-
Seizures with brief loss of consciousness
petite mal
-
____ is a nosebleed. when this happens, just hold firmly against the nasal septum for 10 minutes. do NOT have them
- epistaxis
- lie down, blow nose or talk
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