-
Alemtuzumab
- CD25 target
- binds to B cells and so marks them for destruction via cell-based immunity.
- Used in B-cell CLL, multiple sclerosis
-
Aspirin
- Non-selective COX inhibitor
- Anti thrombotic at low doses
- irreversible inactivation
- side effects: salicylate poisoning, Reye’s syndrome, hypersensitivity reactions
-
Azathioprine
- inhibitor of immune cell proliferation
- inhibit synthesis of guanosine and therefore inhibit DNA synthesis
-
Celecoxib
COX-2 selective NSAID
-
Cimetidine
- H2 selective antagonist
- Treats gastric ulceration- reduces acid secretion
-
Clarithromycin
Antibiotic eradication of Helicobacter pylori
-
Cyclosporin
- calcineurin inhibitor which inhibit T-cell proliferation
- Inhibits secretion of IL2
-
Dexamethasone
long acting corticosteroid
-
Dimenhydrinate
- CNS-penetrant antihistamine
- Treats motion sickness
- H1 antagonists
-
Ibuprofen
- NSAID
- reversible and competes with arachidonic acid for binding within COX enzymes
- Non-selective between COX1 and COX2
-
Infliximab
- Bind TNFα
- used to treat rheumatoid arthritis, crohn's disease
-
Ipratropium
- Muscarinic antagonist
- Against asthma and COPD
-
Loratidine
- Antihistamine, H1 receptor
- Third generation antagonist
-
Methotrexate
- Rheumatoid arthritis
- antiproliferative drug used in cancer chemotherapy
- inhibits folate biosynthesis and DNA duplication by reducing availability of thymidine
-
Metoclopramide
- Anti-emetic drug used in the treatment of chemotherapy-induced nausea
- D2 antagonist
-
Mycophenolate
- Inhibits guanosine synthesis and so prevents B, T cell proliferation
- Transplantation and immunosuppression
-
-
Omeprazole
- Proton pump inhibitor (reduces gastric acid secretion)
- Treat gastric ulcers
-
Ondansetron
5HT3 antagonist used as anti-emetic
-
Paracetamol
- NSAID
- Non-selective COX inhibitor. Little anti-inflammatory action
-
Prednisolone
Short-acting corticosteroid
-
Ranitidine
- H2 receptor antagonist – reduces gastric acid secretion
- Treat gastric ulcers
-
Scopolamine
Muscarinic antagonist used as anti-emetic
-
Sirolimus
- Inhibits mTOR - blocks late activation of T and B cells
- Transplantation and immunosuppression
-
Sulfasalazine
- used to treat rheumatoid arthritis
- Interferes with lymphocytes
-
Sumatriptan
Class of 5HT1D agonists used to control migraine
-
Tacrolimus
- Calcineurin inhibitors. Inhibit secretion of IL2
- Transplantation and immunosuppression
-
Zafirlukast
- Leukotriene D4 and E4 receptor antagonist
- used to treat asthma and COPD
-
Zileuton
- Inhibitor of 5-lipoxygenase (inhibits production of leukotrienes)
- used to treat asthma and COPD
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