Microbiology - Antimicrobial therapy

  1. Who coined the term chemotherapy?
    Paul Ehrlich also coined term magic bullet
  2. Antibiosis
    Againest life
  3. Antibiotic who coined it and what is it?
    Selman Waksman, a chemical substance produced by microorganisms which has the capacity to inhibit the growth of bacteria and destroy bacteria
  4. Synthetic
    Drugs synthesized in a lab
  5. Bacteriocidal
  6. Bacteriostatic
    growth inhibiting
  7. What did Paul Erhlich use to treat syphilis?
  8. Who invented Sulfa drugs?
    Gerhard Domagk and Fourneau
  9. Fleming?
    Discovered Penicillin
  10. Chain and Florey?
    Brought Penicillin to the forefront of american medicine
  11. What is selective toxicity?
    harming of the microbes without significant harm to the host
  12. Modes of Action antibiotics
    Inhibition of cell wall synthesis, disruption of cell membrane function, inhibition of protein synthesis, action of antimetabolites, inhibition of nucleic acid synthesis
  13. What are examples of drugs that inhibit cell wall synthesis?
    Penicillin, bacitracin, cephalosporin, vancomycin
  14. What are drugs that inhibit call membrane function?
  15. What are drugs that inhibit protein synthesis?
    tetracycline, erythromycin, streptomycin, chloramphenicol
  16. What are drugs that disrupt the action of antimetabolites?
    sulfonamide, trimethoprim
  17. Drugs that inhibit of nucleic acid synthesis?
    rifamycin, quinolones, metronidazole
  18. What chemical structure do drugs like penicillin and cephalosporn contain?
  19. What allows the disruption of bacterial protein synthesis and not the host.
    It attacks the 70S ribosomes. Not 80S
  20. Which ribosome does streptomycin act on?
  21. What ribosome does Chloramphenicol and erythromycin act on?
  22. Sulfanilamides interrupt what cell function in bacteria?
    The production of folic acid through PABA
  23. How do antimetabolites function?
    By competitively inhibiting enzymes, being erroneously incorporated into important molecules
  24. What are the three side effect types?
    Toxicity, allergy, disruption of normal flora
  25. How can resistance occur?
    The drug hides in other parts of the body, shift to L form
  26. 5 basic mechanisms associated with bacterial resistance
    Alteration of targets, alteration of membrane permeability, development of enzymes that destroy or inactivate antibiotic, alteration of an enzyme, alteration of metabolic pathway
  27. How to limit drug resistance?
    High enough levels maintained in the body, two antibiotics simultaneously, limiting antibiotics to essential uses only
  28. What is the rate of cure for TB?
    6 months
  29. What are the antifungal agents?
    Imidazole and traizoles, polyenes, griseofulvin
  30. What are the two polyenes?
    Amphotercin B, Nystatin
Card Set
Microbiology - Antimicrobial therapy
Microbio steiner