MJC Micro

  1. Acne (Propionibacterium acnes)
    • *Gram + rod
    • *Digests Sebum
    • *Attracts Neutrophils
    • *Neutrophil digestive enzymes cause lesions, "pus pockets"
    • *Most common skin disease in humans

    • *Bonzoyl peroxide-dries plugged folicles, kills microbes
    • *Tetracycline (antibiotic)
    • *Accutane-inhibits sebum formation
  2. Impetigo
    *Caused by Staphyloccus aureus
    *Streptococcus pyogenes
    • Peeling Crusty Skin
    • Contagious
  3. Staphyloccus aureus
    (caustive agent of impetigo)
    • *Associated with a number of diseases, including impetigo
    • *Enzymes are virulence factors
    • *Most treated pathogen

    *A positive coagulase test is a primary method of identifying staphyloccus aureus
  4. Necrotizing Fasciitis
    "Flesh Eating Strep"
    • Streptococcus pyogenes (Group A Strep)
    • *Tissue digesting enzymes
    • *Rapidly spreading cellulitis may lead to a loss of limb
    • *Disease starts as localized infection, pain in area, flu-like symptoms
    • *Invasive and Spreading
    • *may lead to toxic shock (drop in blood pressure)
    • *30-70% mortality rate
    • *surgical removal
  5. Hansen's Disease: Leprosy
    (myobacterium leprae)
    • *Disease of skin and nerves
    • *change of pigmentation, loss sensation
    • *slow progressing
    • *transmits poorly
    • *droplet or skin contact
    • *Slow growth, prefers cool areas of body
    • *acid fast bacterium
    • **Armadillas harbor bacteria
  6. Virus Infections of the skin: Rashes
    • Measles virus(Rubeola)
    • Rubella Virus (german measles)
    • Roseola (human herpesvirus-6)
    • Fifth Disease (human parvovirus B19)
  7. Measles
    • Viral infection through aerosl droplet: One of the most communicable viruses
    • *local infection lymph nodes (of the neck)
    • *lymphocyte associated viremia, fever, malaise
    • *Spread throughout the body
    • *shed in respiratory tract secretions, Kopliks spots & skin rash
    • *recovery, life long immunity
    • *Measels is the leasing cause of vaccine preventable death among children

    ***The primary reason for ongoing high childhhod deaths is the failure to deliver at least one of the measles vaccine.
  8. Rubella
    • *Viral infection through aerosol droplet; systemic infection
    • *Mild rash
    • *serious to the fetus when contracted in the first trimester of pregnancy
    • *Congenital Rubella Syndrome
    • *small birth weight, blindness, hearing loss, mental retardation
    • *infection lasts for months to years iin the newborn
    • MMR vaccine highly effective
  9. Virus Infections of the Skin : Vesicles
    • Smallpox (Human Pox Virus)
    • Cold Sores (Human simplex 1 & 2)
    • Chickenpox (Human herpesvirus-3)
  10. Chicken Pox
    • Common Virus; decreasing disease in the USA due to effective childhood vaccine.
    • *Benign disease with life long immunity
    • *May reemerge as shingles (skin lession):cause: stress, xrays, drugs

    • *local infection in the lymph nodes
    • *lymphocyte associated viremia, fever, malaise
    • *spread throughout the body
    • *shed is respiratoy tract secretions and skin vessicles (blisters of clear fluid)
    • *life long immunity
  11. Small Pox
    • *Very infectious viral disease epidemic)
    • *a Jennerian vaccine (named for Edward Jenner, 1796)
    • *This virus has been preserved in government labs by agreement, at CDC in Atlanta, and in Russia
    • *Considered a bioterrorism agent
  12. Warts & Papillomas
    • Mostly a benign viral infection
    • *nearly everyone is infected
    • *different virus types
    • -plantar warts
    • flat warts
    • genital warts
  13. Fungal Skin Infection(mycosis): Ringworm
    • Fungal Infection (mycosis)
    • -dermatophyte
    • Conditions name-tinea
    • scalp-capitas
    • beard-barbae
    • body-corporis
    • groin-cruris
    • foot- pedis
    • hand -poris
    • nail- unguium
  14. Virus Infections of the Eye
    • Herpesvirus Keratitis (Human simplex 1)
    • Chlamydial infection of the eye
    • Chlamydia trachomatis causes trachoma and can lead to blindness

    **Both are spread by contact with infected secretions
  15. Infectious Diseases of the Nervous System

    Nervous System
    • CNS: brain and spinal cord
    • PNS: peripheral nerves
    • -Cells are called neurons
    • -No normal flora
  16. Natural Defenses of the Nervous System
    • -Skull and Vertebrae
    • -Microglial cells and macrophages
    • -Restricted entry into brain (blood-brain barrier) for:
    • microorganisms, medications, including most antibiotics, immune system
  17. Nervous System Diseases
    Can be caused by both bacteria, viruses & parasites
  18. Meningitis
    inflammation of the meninge= membranes surrounding the brain and spinal cord
  19. Encephalitis
    Inflammation of the brain
  20. Viruses
    • Arbo (arthropod-borne) viruses
    • -Ex. West Nile Virus
    • Rabies
    • Poliomyelitis
    • Neurotoxins
    • Tetanus
Card Set
MJC Micro
Lecture #19 Infectious Disease of the Skin, Eyes 7 nervous System