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What is first pass effect
The medication pass through the GI tract the medication passess through the liver, may partially or completly inactivate many medications.
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Whats a medications Half life
The time it takes a medication doasge to cut in half.
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5 factors that effect medications response
- Age
- Body mass
- Gender
- Environmental milieu
- Time of Administration
- Pathologic state
- genetic state
- Psychological factors
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Name differance between Sympathetic and Parasympathetic nervous system
- Sympathetic- Fight or flight, comes from the t1-L2 of the spinal cord
- Parasympathetic- Rest and digest, from brain and sacarl portions of the spine.
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Name actions of Bata 1
- Increase Heart rate
- Increase contractile force
- Increase automaticity
- Peripheral vasodilation
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What is the differance between Efficacy and Affinty
- Affinty-the tendency of a medication to combine with specific medication receptor
- Efficacy-The power of a medication to produce a therapeutic effect
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What are the 6 rights of medication adminstration
- Right
- patient
- medication
- dose
- route
- time
- documentation
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What are the 4 stages of medication development
- Stage 1- Pre-clinical- find the medications pharacokinetics,tocicity and safe dose in humans
- stage 2- Clinical research-Find the therapeutic levels and toxic levels
- Stage 3-New drug application-refine therapeutic level and collect relvant data on side effects
- Stage 4-Post marketing-voluntary, medication maker to monitor it's proformance
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What are neurotransmitters?
- Acetylcholine- utilized the postganglionic and preganglionic nerves of the parasympathetic nervous system
- Norepinephrine-Primary postganglionic neurotransmitter of the sympethetic nervous system
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What receptors are primarily responsable for parasympethetic respose
Muscarinic
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Indicators for Endotacheal intubation
- Respiratory or Cardiac arrest
- Unconsciousness
- Risk of aspiration
- Obstruction do to foregin body
- Respiratory extremis due to disease
- Pneomothorax,hemothorax with respiratory difficulty
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What is strider
Upper airway problem
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4 phases of Pharmacokinetic
- Absorption
- distribution
- Biotransformation
- elimination
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4 forms of modified breathing
- Coughing
- Sneezing
- Hiccoujhing
- sighing
- grunting
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Made use and control of narcortics
Comprehensive drug abuse prevention and control act of 1970
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Differance between Non depolarizing and deolarizing
- Nondepolarizing agents block the uptake of acetycholine asb do not allow stimulation of the muscle. thus they do not produce fasciculations
- Depolarizing- Succs most common paralytic agent for RSI
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Act of 1938
Federal food,drug and cosmetic act. Truth in labeling
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What is Potentiation
Enhancement of one medication's effects by another (barbiturates and alcohol)
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L.E.M.O.N
- Look
- Evaluation 3-3-2
- Mallenpati Score
- Obstruction/obesity
- Neck- no neck
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MOANS
- Mask seal
- Obesity
- Age
- No Neck or no teeth
- Stiffness
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Esophageal intubation
- Absence of chest rise and fall
- Gurgling sounds over the epigastrium
- Distention of the abdomen
- absence of breath condensation in the tube
- present leak, dispite inflation of tubes distal cuff
- Cyanosis and progressive worsening of pt's condition
- Phonation(noise made by the vocal cords)
- No color change with colormetric detector
- falling pulse oximetry rreading
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what is respiration
Exhange of oxygen and carbon dioxide in the lungs at the cellular level
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Pharmacokinetics
study of how medications enter the body, reach their site of action, and eventually become eliminated.
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Pharmacodynamics
The study of a medications action on the body
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