-
Hgb composition?
- A (2 alpha, 2 gamma) 95-97%
- A2 (2 alpha, 2 sigma) 2-3%
- F (2 alpha, 2 gamma) 1-2%
-
What is Hgb S?
- Sickle cell anemia
- valine substituted for glutamic acid at position 6
-
What is Sickle Cell crisis?
- Sudden weakness
- rapid pluse
- faintness
- pallor of lips and mucous membrane
- enlarged spleen
-
Laboratory Findings for Sickle Cell
- low Hbg, Hct, RBC
- RBC indices; normochromic, normocytic
- increased reticulocyte
- bone marrow hyperplasia
-
Sickle Cell trait?
usually present with hemolytic anemia except crisis
-
Hgb C
- lysine replace glutamic acid
- forms crystals
|
|