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Retavase

  1. Retavase

    Names / Class
    Reteplase Recombinant

    Fibrinolytic
  2. Retavase

    Mechanism of Action
    Increased formation of plasmin which breaks down the fibrin matrix of a clot.
  3. Retavase

    Onset of Action
    Peak Effect
    Duration
    Half-Life
    • <5 minutes
    • Varies
    • Varies
    • 13 - 16 minutes
  4. Retavase

    Indications
    • Acute coronary syndrome
    • Acute MI
  5. Retavase

    Contraindications
    • Prior intercranial hemorrhage
    • Structural cerebral vascular lesion
    • Malignant intercranial neoplasm
    • Ischemic stroke within 3 mos EXCEPT within 3 hours
    • Aortic dissection
    • Significant closed head/facial trauma within 3 mos
  6. Retavase

    Benefits must outweigh Risks:
    • Hx of chronic, severe, poorly controlled HTN
    • Severe uncontrolled HTN on presentation (SBP >180 mmHg or DBP >110 mmHg).
    • Hx of prior ischemic stroke >3 mos, dementia, or known intracranial pathology.
    • Traumatic or prolonged (>10 min) CPR or major surgery (<3 weeks).
    • Recent internal bleeding (past 2 - 4 weeks)
    • Noncompressible vascular punctures
    • Pregnancy
    • Active peptic ulcer
    • Current use of anticoagulants
  7. Retavase

    Precautions
    • Anaphylaxis (rare)
    • Resuscitative drugs & equipment should be readily available
    • Antiarrythmic meds should be available
  8. Retavase

    Side Effects
    • Bleeding
    • Allergic Reactions
    • Anaphylaxis
    • Fever
    • Nausea
    • Vomiting
  9. Retavase

    Adult Dose
    • 10 units IV over 2 minutes.
    • Repeat 10 units IV over 2 minutes in 30 minutes.
    • (20 units total)
  10. Retavase

    Pedi Dose
    Not Indicated
  11. Retavase

    Max Dose
    20 units
  12. Retavase

    Routes / How Supplied
    IV

    Unknown
Author
Ritameeker
ID
207641
Card Set
Retavase
Description
Retavase / Reteplase Recombinant
Updated

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