45-46

• premature chain termination
• Euk, Prok

No clinical use/ cause premature chain termination due to low affinity to the P site

both euk and prokaryotes (but selectively concentrated in bacteria)

prevent aminoacyl-tRNA from binding to A site ( elongation?)

• initiation (prevent fmet tRNAf binding to the P site) , misreading of mRNA
• prokaryote

• peptidyl transferase (elongation)
• prokaryotes

• peptidyl transferase (elongation)
• eukaryotes

• blocks translocation
• prokaryotes