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Norepinephrine

  1. Norepinephrine

    Names / Class
    Levophed

    Sympathetic Agonist
  2. Norepinephrine

    Mechanism of Action
    Causes peripheral vasoconstriction due to effects on alpha - causing an increase in BP.
  3. Norepinephrine

    Onset of Action
    Peak Effect
    Duration
    Half-Life
    • Immediate
    • <1 minute
    • 1 - 2 minutes
    • 3 minutes
  4. Norepinephrine

    Indications
    Hypotension: systolic <70 mmHg, NOT due to hypovolemia.
  5. Norepinephrine

    Contraindications
    Hypotension due to hypovolemia
  6. Norepinephrine

    Precautions
    • Fluid replacement should be initiated first.
    • Use caution if Pt is on beta blockers.
    • Give through largest vein readily available as tissue necrosis can occur if medication extravasates.
    • Increases myocardial oxygen demand: use with caution in Pt with myocardial ischemia.
    • Can be deactivated with alkaline solutions such as Sodium Bicarbinate.
    • Constant monitoring of BP is essential.
  7. Norepinephrine

    Side Effects
    • Anxiety
    • Palpitations
    • HA
    • HTN
    • Nausea / Vomiting
    • Bradycardia
    • Improves renal blood flow and urinary output in septic Pts.
  8. Norepinephrine

    Adult Dose
    • Dilute: 8 mg in 500 mL D5W (16 mcg/mL)
    • OR
    • 4 mg in 250 mL D5W (16 mcg/mL)
    • ****************************
    • 0.1 - 0.5 mcg/min per AHA, however higher doses may be required to maintain adequate BP.
    • Should be piggybacked into an existing IV infusion & administered via a controlled pump.
  9. Norepinephrine

    Pedi Dose
    • 0.01 - 0.5 mcg/kg/min
    • (rarely used)
  10. Norepinephrine

    Max Dose
    30 mcg/min
  11. Norepinephrine

    Routes / How Supplied
    IV drip only, with a controlled pump if possible

    Vial
Author
Ritameeker
ID
206882
Card Set
Norepinephrine
Description
Norepinephrine / Levophed
Updated

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