-
NNDI if clinical trials
agomelatine - valdoxen
-
TCA tertiary
tabs and injection
discontinued but back on the market
amitriptyline
-
TCA tertiary
ind - OCD
high incidence of sexual dysfunction
high serotonin uptake
clomipramine - anafranil
-
TCA tertiary
not recommended for <12 yo
moderate serotonin uptake
doxepin - silenor
-
TCA tertiary
ind - depression and childhood enuresis <6
high orthostatic compared to other TCA's
imipramine - tofranil
-
TCA tertiary
slight serotonin and norepinephrine uptake blocker
trimipramine - surmontil
-
TCA secondary
high NE uptake blocking activity and anitcholinergic effects
not for kids, T1/2 67-89 hrs
protriptyline - vivactil
-
TCA secondary
not for kids < 16 because of 50-600mg/day
high anticholinergic and moderate sedation effect
second generation agent
amoxapine
-
TCA secondary
moderate NE and high 5HT uptake block
caps and solution
nortriptyline - pamelor
-
TCA secondary
least anticholinergic, sedation and othostatic hypotension
despiramine - norpramin
-
Tetracycline
CI in pts with known or suspected seizure disorders
block NE reuptake
maprotiline
-
tetracycline
potent 5HT2&3 receptor antagonist
potent antagonist of H1 = prominent sedative effect
SE - agranulocytosis, 30 day Rx then bloodwork
mirtazapine - remeron
-
triazolopyridine
ind - depression, alcoholism, aggressive behavior, cocaine withdrawal
moa - selective inhibits serotonin reuptake and potentiates 5-hydroxytryptophan
onset of action - 2-4 wks
AE - inappropriate or painful erections
trazodone - oleptro
-
aminoketone
ind - depression, smoking cessation, adunct in diabetes
associated with seizures and frequency increases with dosage
weight gain
bupropion - wellbutrin
-
once daily prep of bupropion
alplenzin
-
phenythylamine
SNRI
AE - rash or hives or other allegic reactions occur
venlafaxine - effexor
-
main metabolite of venlafaxine
desvenlafaxine - pristiq
-
SNRI
potent inhibitor of neuronal 5HT and NE reuptake and less DA
ind - MDD, major mood disorder
fibromyalgia
duloxetine - cymbalta
-
SNRI
racemic
ind - fibromyalgia
no QT issues
not approved for pediatric use
milnacipran - savella
-
phenylpiperidine
tab
may cause liver damage
nefazodone
-
SSRI
ind - bulimia nervosa
tabs, pulvules, oral solution
T1/2 - 1 to 348 hrs
secondary amine
fluxetine - prozac
-
SSRI
ind - OCD
T1/2 14-16 hrs
fluvoxamine - luvox
-
SSRI
ind - panic disorder, social anxiety
max dose for pts with severe renal or hepatic impairment is 40mg/day
caution on withdrawal - develop psychiatric problems
paroxetine - paxil
-
SSRI
ind - PTSD
T1/2 - 26-104hrs
secondary amine
sertraline - zoloft
-
SSRI
genetic, GRIK2, AMPA, GR1A3 - link to suicidal ideation
QT elongation
no weight gain, lower SE
citalopram - celexa
-
SSRI
ind - Tx of major depression
highly selectivve
escitalopram - lexapro
-
SSRI & 5HT1A partial agonist
not for pediatric pts
must be taken with food
vilazodone - viibryd
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