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RadTherapy
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BPH?
benign prostatic hyperplasia
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PSA?
prostate specific antigen (under 1 is good)
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Treat the ____ prostate.
whole
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____ cell patients do better than adeno.
Squamous
-
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hockey stick shape field is always ____?
seminoma
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Prostate
testicular
penile/urethra
how common??
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Incidence of prostate ca:
____ although there appears to be some ____ relationship.
Often found concurrently w/ ____ ____ ____.
- unknown
- hormonal
- benign prostatic hyperplasia
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Penile/male urethra incidence:
Higher in ?
Penile ca is related to ____ ____?
Urethral ca is linked to chronic ____ and infections, ____, ____ diseases, and stictures.
- Asia, Africa, South America
- neonatal circumcision
- irritation
- HPV
- venereal
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Testicular cancers are rare, but ____ common ____ in men ages 20-34. Incidence is higer in males w/ ____ ____. (cryptoorchidism) Most common in ____ from the US, UK, and Denmark.
- most
- malignancy
- undescended
- testes
- caucasians
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Pathology:
prostate- ____ is most common.
penile lesions- well differentiated ____ ____.
urethral lesions-well to moderately differentiated ____ ____.
prostatic urethral lesions- ____ ____.
bulbomembranous urethral lesions-____.
testicular- 95% ____ cell. (seminoma 35-50%)
- adenocarcinoma
- squamous cell
- squamous cell
- transitional cell
- adenocarcinomas
- germ
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TURP?
transurethral resection of the prostate
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Most common age:
prostate-
penile/urethra-
testicular-
- after age 65
- 58-60
- between ages 20-34
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XRT doses:PROSTATE
nodal doses?
seminal vesicle?
prostate?
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XRT dose for penile/urethra ____Gy?
include ____ nodes.
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XRT dose: TESTES
seminoma- ____cGy for stage I and stage IIA, boost of ____ -____cGy for stage IIA and higher.
nonseminoma (____) RT has ____ role in these tumors, except ____ of brain or other mets areas.
- 2500
- 500-600
- radioresistant
- little
- palliation
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Histology: PROSTATE
Cancer is ____ and developes in the ____ of the prostate. Benign is ____. ____ invasion is ____ is most ____ cases.
- multifocal
- peripheral
- central
- Perineural
- present
- all
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Detection and Diagnoses: PROSTATE
(7) CCCDPMT
- -complete physical & rectal exams
- -cystocopy
- -CT
- -diagnosis obtained through a trasrectal sonography guided needle biopsy
- -PSA (normal is 4ng/ml or less)
- -MRI
- -transurethral ultrasound
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____ is used for staging prostate ca.
Gleason
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Prostate ca is the most common ____ in men. _:_ will develope in their lifetime. ____ ____ have one of the highest ____ in the world and a worse ____. Incresed risk in ____, Sweden, and ____. Decreased risk in ____, Taiwan, and ____ ____. Overall a slow growing malignancy.
- malignancy
- 1:6
- African Americans
- incidences
- prognosis
- US
- Europe
- Japan
- Jewish men
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Prognostic factors for prostate ca? (4) (TRPL)
- Tumor stage
- Race
- PSA
- Lymph node status
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As prostate ca grows, it may ____ into and through the ____ , invade ____ tissue, ____ vesicales and eventually the ____ or ____.
- extend
- capsule
- periprostatic
- seminal
- bladder
- rectum
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Treatment techniques for prostate ca?
____ for patients over 75. ____ T1 or T2 stage disease and life expectancy of at least 10 years. ____ ____ regresses prostate tumor. ____ mostly used for mets disease. ____ ____ positively charged particles deliver dose. (Bragg's peak)
- observation
- prostatectomy
- hormonal therapy
- chemotherapy
- proton therapy
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Hormonal therapy examples? (4)
- Zoladex
- Lupron
- Flutamide
- Casodex
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Testes routes/sites of spread.
seminoma: ____ to lymph nodes of ____, mediastinal, and ____ nodes. Only ____ stage disease spread hematogenously to the ____, bone, ____ or brain.
- Orderly
- retroperitoneum
- scv
- late
- lung
- liver
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Testes:
nonseminomas- metastasize outside the ____ ____ involving lungs and ____.
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Prostate major sites of spread are ____ and ____ ____. Blood goes to the ____, liver, and ____. Lymph nodes spread first to ____ and ____ nodes, followed by external ____, hypo gastric, common iliac, and ____ ____.
- Blood
- lymph nodes
- bone
- brain
- Periprostatic
- obturator
- iliac
- para aortics
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