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Leprosy treatments

  1. Treatment for Tuberculoid leprosy
    • Dapsone 100 mg po qd PLUS
    • Rifampin 600 mg po qd

    6-12 months
  2. Treatment for Lepromatous leprosy
    • Dapsone 100 mg po qd PLUS
    • Rifampicin 600 mg po qd PLUS
    • Clofazimine 50 mg po qd

    24 months
  3. Dapson MOA
    inhibits dihydropteroate synthase; inhibits folic acid synthesis

    weakly bactericidal
  4. Dapsone dose adjustements
    none
  5. Dapsone AEs
    • screen for G6PD deficiency
    • hepaitis
    • jaundice
    • leukopenia
    • peripheral neuropathy
  6. clofazimine MOA
    DNA binding
  7. clofazimine AES
    skin discoloration - inc melanin pigmentation
Author
jcu1
ID
205411
Card Set
Leprosy treatments
Description
Gillis
Updated

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