med chem III quiz 5 antiinflammatory

2 NSAID sulfonamides

NSAID COX-2 selective

5-HT_1D agonist for migraine

5-HT_2A/2C antagonist for migraine and depression

serotonin 5-HT₁ agonist
not for prophylaxis
dosing must be nor more often than q2h

serotonin 5-HT₁ agonist
use extreme caution in hepatic failure can result in extreme BP elevation

serotonin 5-HT₁ agonist
more selective
metabolized by MAO & CYP3A4 &2D6

serotonin 5-HT₁ agonist
contraindicated in pts with severe renal or hepatic failure

serotonin 5-HT₁ agonist
ind - acute Tx of migraine attacks w/ or w/o aura
26 hr 1/2 life - better compliance - 1tab Tx

serotonin 5-HT_1B/1D agonist
not for prophylaxis
CI in ischemic heart disease

ergot alkaloid
most famous
schedule 1

ergot amino derivative
nasal spray

ergot amino derivative

chronic migraine dealing with head skin pain

sensation of whirling or rotating accompanied by involuntary swaying, weakness and lightheadedness

functional disorder caused by repetitive angular, linear or vertical motion

antidopaminergic
phenothiazine
ind- intracable hiccoughs
SE thorazine shuffle
CI in < 6mo, unless life saving

antidopaminergic
phenothiazine
ind- antihistamine for type I hypersensitivity & motion sickness (pre&post surgery)

antidopaminergic
non-phenothiazine
ind - N/V in cancer chemotherapy & preg & labor

given if extrapyramidal symptoms occur from reglan

anticholinergic
antihistamine
piperazine
ind - motion sickness
CI with morphine or resp. depressants

anticholinergic
antihistamne
ind - N/V
oral use only antihistamine
moa - depressant action on the hyperstimulated labyrinthine

anticholinergic
moa - obscure (may inhibit CTZ but direct signals to the VC are NOT)

anticholinergic
ind - motions sickness
not for children
dry mouth, caution in parkinson pts

5-HT_1A partial agonist for anxiety and depression
no anticonvulsant activity or muscle relaxant properties
3-4 wks to see results

5-HT₃ antagonist for chemo-induced emesis
N/V due to APAP poisoning
oral disintegrating tabs

5-HT₄ agonist for GI disorders

5-HT transporter inhibitor for depression, O/C, panic, PTSD

5-HT₃ anagonist
caution in pts w/ QT abnormalities, taking diuretics
don't mix IV with other drugs
can mix w/ apple/grape juice for peds

5-HT₃ anagonist
tab, inj, transdermal
monitor liver cancer pts carefully

5-HT₃ anagonist
ind - irritable bowel syndrome (women only)
tab
SE severe constipation leading to perforated colon

5-HT₃ anagonist
N/V cancer chemotherapy 30 min prior
not recommended to redose within 7d
no CYP induction or inhibition

5-HT₄ partial agonist
available through special access programs
short term Tx IBS in women
not for diarrhea-prominent IBS

cannibinoid
ind - antiemetic cancer chemotherapy
schedule 3
unlabeled - appetite stimulation (AIDS pts)
pts remain under supervision of adult

cannibinoid
oral synthetic
ind - antiemetic cancer chemotherapy
schedule 2
<1% reaches the brain, CYP metabolized

substance P/neurokinin 1 receptor antagonist
N/V chemotherapy including high dose cisplatin
augments 5-HT3 antagonist activity

misc. agent
ind - N/V from intestinal and stomach flu
and food and drink indiscretions

anti-anxiety
BZ
ind - PMS, panic disorder w/ or w/o agoraphobia

anti-anxiety
BZ
ind - adjunct in partial seizures

anti-anxiety
BZ
ind - preoperative apprehension

anti-anxiety
BZ
muscle relaxant
solution, tab, inj, rectal gel

anti-anxiety
BZ
ind -status epilepticus
chronic insomnia
tab, inj, sol

anti-anxiety
BZ
ind - alcoholics with acute tremulouness
caps

anti-anxiety
ind - psychoneurosis pts - sleep disturbances
TCAD with anti-anxiety properties
not recommended for <12yo

anti-anxiety
ind - prior to dental appt
moa - subcortical area CNS depressant-ataraxic
tab,cap, syrup, susp inj

anti-anxiety
ind  - effectiveness of >4 mo unknown
moa- carbamate derivative
may precipitate seizures in epilepsy, slowly withdraw

2 salicylates not hydrolyzed to salicylic acid

lethal doses of salicylic acid

non-selective COX inhibitor
swallow tabs whole, no chewing

2 NSAIDs not used for RA of osteoarthritis

synthesized continuously COX

inducible COX

NSAID
acetic acid 6

NSAID
proprionic 7

NSAID
acetic
prodrug

NSAID
acetic
patch, gel, combo w/ misoprostol

NSAID
propionic
first intranasal

NSAID
N-Arylanthranilic acid
fenamic acid derivative