What are the primary functions of the immune system, and consequently how can it go wrong?
Protect the body from foreign invasion- has the ability to identify self from non-self
Clean up debris- isolate and phagocytosis
Prepare tissue for healing-inflammation, tissue restoration or scarring
Which antibodies are responsible for recognizing foreign invaders
T lymphocytes and B lymphocytes can recognize any foreign antigen to fight infection
What do kinins/bardykinins do?
Wall off pathogens
Organs of immunity: thymus
T Lymphocytes migrate to the thymus to mature and then are released into circulation
Organs of immunity: spleen
Recycles iron from RBCs
White cells for blood borne protection
What do you need to know about leukocytes
Named after granules in the cytoplasm and perform phagocytosis
Immature Neutrophils are called “Bands”, requiring 14 days for maturity
What do you need to know about granulocytes?
Lymphocytes- Granulocytes with “Natural Killer”
abilities- small Lymphocytes are T and B Cells
What type of granulocyte is involved in allergic rxn and parasite invasion?
What is a basophil?
stimulate inflammatory response- have histamine, bradykinin and heparin granules
Mast cells are basophils found in the tissues
What's a neutorphil?
Chief phagocytes of early inflammation
Shoot lysosmal granules dissolve cellular debris to prepare site for wound healing
What are agranulocytes?
Most powerful at phagocytosis
Do not contain granules, can ingest dead host cells such as blood cells
Monocytes and macrophages are agranulocytes
Monocyte is immature macrophage
--respond quickly to inflammation
What do macrophages do?
Significantly initiate inflammatory response
Larger and more phagocytic than monocytes
Adult MedSurg 2