Immunology Intro

• Protect the body from foreign invasion- has the ability to identify self from non-self
• Clean up debris- isolate and phagocytosis
• Prepare tissue for healing-inflammation, tissue restoration or scarring

T lymphocytes  and B lymphocytes can recognize any foreign antigen to fight infection

• Cause inflammation
• Wall off pathogens

T Lymphocytes migrate to the thymus to mature and then are released into circulation

• Lymph filtration
• Recycles iron from RBCs
• White cells for blood borne protection
• Blood reservoir

• Granulocytes (55-60%)
• Named after granules in the cytoplasm and perform phagocytosis
• Immature Neutrophils are called “Bands”, requiring 14 days for maturity

• Lymphocytes- Granulocytes with “Natural Killer”
• abilities- small Lymphocytes are T and B Cells

eosinophils

stimulate inflammatory response- have histamine, bradykinin and heparin granules

Mast cells are basophils found in the tissues

• Granulocyte
• Chief phagocytes of early inflammation
• Shoot lysosmal granules dissolve cellular debris to prepare site for wound healing

• Most powerful at phagocytosis
• Do not contain granules, can ingest dead host cells such as blood cells
• Monocytes and macrophages are agranulocytes
• Monocyte is immature macrophage
• --replenish macrophages
• --respond quickly to inflammation

• Significantly initiate inflammatory response
• Larger and more phagocytic than monocytes