Sodium ECF concentration?
Calcium ECF concentration?
Glucose ECF concentration?
Fasting 3.5-6 mmol/L
Non fasting 3.5-8 mmol/L
Potassium ECF concentration?
Core body temperature?
About 37C (36-38C)
Sodium ECF function? (3)
Main extracellular cation
Determines ECF volume and therefore influences blood pressure
Action potential generation - nerve/muscle
Calcium ECF function? (4)
Structural component - bone and teeth
Neurotransmission and muscle contraction
Regulates enzyme function
Glucose function? (1)
Used by cells - produce adenosine triphosphate (ATP)
Potassium ECF function? (2)
Most abundant ICF cation
Determinant resting membrane potential
Low core body temperature issues? (2)
Chemical reactions slow down preventing cell function
Complete loss of temperature regulation
High core body temperature issues? (2)
Denaturing of enzymes
Temperature regulation impairment
Passive membrane transport systems? (3)
Simple diffusion via membrane channels
Carrier mediated passive transport
Osmolarity of ECF/ICF?
Measure of total number solute particles per litre of solution in osmol/L
Define tonicity and how it is influenced.
Effect a specific solution has on cell volume.
Influenced by type of solution - specifically whether solute particles can cross cell membrane
Describe effect of Isotonic solution.
No change in cell volume
Describe effect of Hypotonic solution.
Increase in cell volume - cells will swell
Describe effect of Hypertonic solution.
Loss of cell volume - cells will shrink
The maintenance of relatively constant conditions in the internal environment if the face of external or internal change.
Describe the sodium-potassium pump and its function.
An active cell membrane transport system that moves 3 sodium ions out of the cell in exchange of 2 potassium ions.
Maintains ionic gradients and helps regulate cell volume.
Amount of solute particles per kg of water in osmol/kg.
Describe hyperosmotic solution.
Higher solute concentration than cell
Describe hypoosmotic solution.
Lower solute concentration than cell
Describe isoosmotic solution.
Same solute concentration as cell
What is the body water % for males and females by weight?
Male - 60%
Female - 55%
What % of total body water does ECF contribute?
What % of total body water does ICF contribute?
What % of ECF does blood plasma contribute?
What % of ECF does interstitial fluid contribute?
Generall homeostasis, ECF variables, cell membrane transport systems