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what is pharmacology?
study of origin, properties, effects of drugs, on a living organism
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what is the use of absorption?
- an entrance into blood stream
- speed depends on the route
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distribution
movement by circulatory system to cells and tissues until peak blood levels
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what is the metabolism?
a chemical breakdown after use (in liver)
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what is excretion?
elimination (in kidneys)
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where do origins come from?
animals, plants, minerals
most produced synthetically in lab
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what are the solid forms of drugs?
tablets, capsules, caplets, lozenges, creams, ointments, suppositories, transdermal patches
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what are the liquid form of drugs?
elixers (alcohol), emulsions, liniments, lotions, solutions, spirits, sprays, suspensions (shakes), syrups (sugar), tinctures
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ELIXER
- dissolves in solution of alcohol/water
- sweetened or flavored
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EMULSIONS
mixed of fats n oils in water
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LINIMENT
- combined w/ oil, soap, alcohol, water
- applied externally
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LOTION
- external, soothe,
- protect, moisten
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SOLUTION
- has 1 solution
- dissolvable
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SUSPENSION
drug is solid, must shake before use
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TINCTURE
drug dissolves in alochol/water
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SYRUP
- drug dissolves in sugar/water
- flavored
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TABLET
- powdered drug
- pressed into a small disc
- it can be scored
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CAPSULE
- gelatin capsule
- water soluable
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LOZENGES
- candy like
- has a case
- circular size
- dissolves on tongue
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CREAM
- non greasy
- semi-solid
- external
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SUPPOSITORY
- drug mixed w/a firm base
- melts at body temp
- put into vagina/rectum
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PATCHES
- adhesive
- contains a drug
- applied to skin
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federal agency that determines drugs are safe and effective
- FDA (us food & drug administration)
- *for drugs w/o supervision
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agency has regulation over controlled drugs?
drug enforcement agency
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regulate controlled drugs?
- double lock
- count each day
- verified by two pople
- record in log
- submit to DEA
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schedule 1
- highly potential drugs
- no medical use
- prohibited prescriptions
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schedule 2
- high abuse potential
- highly restricted
- prescription in writing
- telephone- only allowed for immm. use. confirm w/i 72 hrs
- no refills allowed
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schedule 3
- some potential for abuse
- accepted medical use
- low to moderate physical dependency
- moderate-high psychological dependency
- prescription written or verbal
- refilled five times w/i 6 months of date prescribed
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schedule 4
- low potential for abuse,
- accepted medical abuse,
- has limited both physical or psychological dependency
- prescription written or verbal
- refilled 5 times w/i 6 months of date prescribed
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schedule 5
- very low potential abuse
- accepted medical use
- low/physical/psychological dependency
- refills determined by provider,
- expires one year,
- available without prescription if under 18
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what book uses for council on pharmacology for medical assocation?
united states pharmacopeia formulary (USP/NF)
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what book is published by medical economics company with cooperation of participating pharmaceutical manufacturers?
Physician's Desk Reference (PDR)
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what is in a Physician's Deesk Reference?
- color coded sections
- actual-size pictures (tables, capsules)
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conditions that a drug is approved to treat?
indications
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what is a harmful affect? like dyspnea, shock, convulsions, loss of consciousness, or even death?
anaphylactic reaction
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what is an abnormal, or unexplainable reaction?
idiosyncratic reaction
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what route is under the tongue?
sublingual
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what route is between gum and cheek?
buccal
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what route is on your skin?
topical
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what is the name of the route that is outside the GI tract and is by injection?
parenteral
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superscription
directions to a pharmacist on prescription
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what is the word describing the directions to a pharmacist on the prescription?
subscription
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DEA NUMBER
phrase needed for controlled substances
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what are the rights of drug administration?
- right patient
- right drug
- right time
- right dose
- right technique
- right route
- right to be educated
- right to refuse
- right documentation
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3 measurement systems
- metric
- apothecary
- household
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measurement systems measure what?
- weight-mass/heaviness
- volume-space occupied
- length- distance from point to point
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metric system
decimal system based on multiples of 10
- basic units:
- weight-gram
- volume-liter
- length- meter
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prefixes of metric system
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abbreviations of metric system
- weight- microgram, milligram, gram, kilogram
- volume- milliliter, cubic centimeter, liter
- length- millimeter, centimeter
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apothecary system
- older, less accurate
- gradually being phased out
- basic units
- weight- grain, scruple., dram, oz, lb
- volume- mini min, fluid dram, fluid oz, pint
- length- inch, ft, yard, mile
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apothecary system abbreviations
weight- grain, scruple, dram, ounce
volume- minim, fluid dram, fluid ounce, pint, quart, gallon
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household system
- least accurate
- pt. use at home
- only in volume
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SYRINGE
- plastic, disposable, safety devides
- inserts fluid into the body
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HYPOERMIC SYRINGE
- cc/ml
- used for IM inj.
- calibrated into tenths
- 1-3 cc/ml capacity
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INSULIN SYRINGE
- calibrated in Unites (U)
- for insulin injections
- 50 or 100 U
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TUBERCULIN SYRINGE
- into tenths/hundreths
- (0.01) CC/ML used for PPD (tuberculin test)
other- 5-60 cc/ml for treatments
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BARREL of syringe
holds medicine
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FLANGE of syringe
- rim at end of barrel
- stabilizes syringe during injection
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PLUNGER of syringe
- moveable inside barrel
- draws medicine into syringe
- pushes medicine out during inject.
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HUB of syringe
connects to the syringe
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SHAFT of syringe
part that is inserted into the tissue
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LUMEN of syringe
- hollow inside of shaft
- medicine flows through it
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GAUGE
- diamter of the lumen
- # increases = diameter decreases
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POINT/BEVEL of syringe
- tip of needle shaft
- it is tapered
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LENGTH of syringe
- depends on type of injet
- sit, size, pt.
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filtered is used with what?
ampule
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VIAL
closed glass container w/ rubber stopper
roll to mix
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AMPULE
- small sealed glass container- single dose
- tap stem & break
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RECONSTITUTION of powdered drugs
adding liquid to powdered drug
- prolongs shelf-life
- follow instructions
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sub-q injection
- needle length- 1/2 to 5/8 inch
- needle gauge- 23 or 25
- upper lateral arm
- upper outer thigh
- upper back
- abdomen
- flank area
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sub-q injection
- 45 degree angle (5/8 inch)
- 90 degree angle (1/2 inch)
- cannot inject more than 1 cc/ml
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common sub-q injection medicines
- epinephrine
- insulin
- allergy injections
- depo
- MMR
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IM injection
- more rapid absorption
- less painful
- for concentrated drugs or irritable/damageable drugs
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common IM injection medicines
- immunizations
- antibiotics
- contraceptives
- vitamin b12
- corticosteroids
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IM injection sites
- delotid
- dorsogluteal (gluetus maximus muscle in buttock)
- ventrogluteal (gluteus medius muscle in hip)
- vastus lateralis (muscle in thigh)
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IM injection length & gauge
- gauge- 18, 21, 23
- length- 1-3 inch (1 1/2 is common)
- insert 90 degree angle
- inject slowly
- aspirate!!!!
- ALLOWED- a bubble
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Z-track
- when skin is pulled sideways to track medicine
- inject @ 90 degree angle
- leave 1/3 of needle exposed
most common site- dorsogluteal
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landmark deltoid
- three finger widths below acromion process
- 1 inch needle
- .5-1.0 cc/ml common
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landmark dorsogluteal
- find greater trochanter and posterior superior iliac spine
- make diagonal line between them
for adults/children over 3 years old
last resort- avoid sciatic nerve & arteries
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landmark ventrogluteal
left sided injection
find greater trochanter, point index finger towards the iliac spine, point pointer finger as far as possible away, inject between the two fingers
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landmark intramuscular injection
find greater trochanter, go at least one hand-width below this, and one hand-width above the knee cap
use for children under 3
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landmark ID (intradermal) injections
anterior forearm, where skin is thin
use for skin testing or TB
needle length- 3/8th or 5/8ths
gauge- 25 or 27
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tuberculin testing methods
Mantoux or TB tine
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mantoux test of TB
- ID
- 3/8 or 1/2 inch,
- gauge 26-27
- 0.10 cc/ml
- anterior forearm
- DONT cover site when finished
- read tests w/i 48-72 hours
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reading of a TB mantoux test
- read w/i 48-72 hours
- read diameter horizontally across
- use mm rule
- positive- 10 mm or more
- doubtful- 5-9 mm
- negative- 5 mm or less
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what is PPD of TB?
purified protein derivative of tuberculin
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allergy includes
allergic rhinitis, hay fever, asthma, urticaria, contact dermatitis, eczema
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direct skin testing for allergies
- extracts of common allergens applied topically to skin (patch test)
- injected into superficial skin layers (skin prick)
- ID injection
read results 20-30 minutes after
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sites for direct skin testing of allergies
- anterior forearm (ID testing)
- upper arm (ID testing)
- middle of back (Path and skin prick testing)
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RAST allergy test
radioallergosorbent assay
draw blood, sent to outside lab
measures amount of antibodies in blood to common allergens
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