causes paralysis of ascaris by blocking acetylcholine at the myoneural junction
PIPERAZINE - Indications
–Not used for other helminth infections
PIPERAZINE - Contraindications
patients with impaired renal or hepatic function
PIPERAZINE - Adverse effects
PIPERAZINE - Drug interactions
Antagonistic with pyrantel pamoate
PRAZIQUANTEL - MOA
Mechanisms of action
–Increases the cell permeability to calcium in schistosomes; causes strong contractions and paralysis of worm musculature leading to detachment of suckers from the blood vessel walls and to dislodgement
PRAZIQUANTEL - Indications
–FLUKES of ALL kinds
What medicine can cause ocular cysticercosis?
What is ocular cysticercosis?
Ocular cysticercosis result from a worm larvae developing in the eye.
What are the treatment considerations concerning ocular cysticercosis?
If medication (Praziquantel) is taken for a worm in the eye the inflammatory response to the dead worm is worse than leaving the worm alive.
PRAZIQUANTEL - Contraindications
hypersensitivity to the drug,
PRAZIQUANTEL - Toxicity
PRAZIQUANTEL - Interactions
Alcohol increases CNS depression,
cimetidine increases praziquantel levels
PYRANTEL PAMOATE - MOA
Stimulates nicotinic receptors present at
neuromuscular junctions of nematodes
Contraction of muscles occurs followed by
a depolarization-induced paralysis.
PYRANTEL PAMOATE - Indications
broad-spectrum anthelminthic for treating pinworms,
and Trichostrongylus orientalis.
PYRANTEL PAMOATE - Toxicity / Adverse effects
PYRANTEL PAMOATE - Contraindications
relatively contraindicated in pregnancy and liver disease
PYRANTEL PAMOATE - Drug Interactions
–piperazine antagonizes the effect of pyrantel pamoate.