Antianginal Drugs

  1. Nitrates/Nitrites Mechanism of Action
    • Dilate all blood vessels
    • ~coronary arteries
  2. Nitrates/Nitrites Indications
    • stable, unstable, and vasospastic angina
    • can prevent
  3. Nitrates/Nitrite Contraindications
    severe anemia, closed-angle glaucoma, hypotension, severe head injury
  4. Nitrates/Nitrite Adverse Effect
    • headache, hypotension
    • reflex tachycardia
  5. Beta-Blocker mechanism reaction
    block beta 1 receptos on the heart
  6. Beta-blocker Indications
    • exertional angina,¬†
    • antihypertensive, cardiac dysrhythmias, cardioprotective effects
    • migraine headaches, essential tremors, stage fright
  7. Beta-blocker contraindications
    • systolic heart failure and serious conduction disturbances
    • bronchial asthma, diabetes mellitus, reduced mental alertness, peripheral vascular disease
  8. Beta-Blocker Adverse Effects
    • decrease in heart rate, cardiac output, cardiac contractility, bronchoconstriction
    • increased airway resistance
    • cardiovascular- hypotension, second or third degree heart block, heart failure
    • Metabolic- altered glucose and lipid metabolim
    • CNS- dizziness, fatigue, mental depression, lethargy, drowsiness, unusual dreams
    • Other: impotence, wheezing, dyspnea
  9. Calcium channel Mechanism of Action
    cause coronary artery and peripheral arterial vasodilation
  10. Calcium channel Indications
    • short term atrial fibrillation and flutter, migraines, Raynaud's disease
    • angina, hypertension, supraventricular tachycardia¬†
    • coronary artery spasms
  11. Calcium channel Contraindications
    acute MI, AV block, hypotension
  12. Calcium Channel Adverse Effects
    hypotension, palpitations, tachycardia, bradycardia, constipation, nausea, dyspnea
  13. Calcium Channel Interactions
    grapefruit juice
Card Set
Antianginal Drugs
Pharm test 3