-
Cyclosporine
- Immunosuppressant
- bind cyclophilin
- inhibits calcineurin => inhibit IL-2 synthesis
-
Tarcolimus
- Immunosuppressant
- binds FKBP
- inhibits calcineurin => inhibit IL-2 synthesis
-
Sirolimus
- Immunosuppressant
- bind FKBP
- inhibits Rapamycin => decrease IL-2 response
-
Azathioprine
- Immunosuppressant
- converted to 6-MP
- inhibit DNA synthesis
-
Mycophenolate Mofetil
- Immunosuppressant
- inhibits inosine monophosphate DH (IMP-DH)
- inhibits GTP syntehsis
-
Leflunomide
- Immunosuppressant
- inhibits pyrimidine synthesis
-
Aldesleukin
- IL-2 analog
- activates lymphocytes
-
Muromonab
- Immunosuppressant
- bind CD3
-
Basiliximab
- Immunosuppressant
- bind CD25 (IL-2Ra)
-
Abatacept
- Immunosuppressant
- inhibits CD28-CD80 interaction
-
Alemtuzumab
- Immunosuppressant
- bind CD52
-
Alefacept
- Immunosuppressant
- prevent CD2 & APC interaction
-
Efalizumab
- Immunosuppressant
- inhibits LFA & ICAM
- inhibits extravascularization of lymphocytes
-
Natalizumab
- Immunosuppressant
- block integrin (tight binding of lymphocytes)
-
Rituximab
- Immunosuppressant
- bind CD20 (CLL)
-
Entanercept
Adalimumab
Inflximab
- Immunosuppressant
- block TNF-a
-
Anakinra
- Immunosuppressant
- inhibits IL-1 receptors
-
methacholine
- Asthma & COPD
- ACh agonist (diagnosis only)
-
Albuterol
Levalbuterol
- Asthma & COPD
- Short acting B2 agonist
-
Epinephrine
Metaproterenol
Terbutaline
- Asthma & COPD
- sympathetic agonist
-
Theophylline
- Asthma & COPD
- Adenosine blocker
-
Beclomethasone
Fluticasone
Trimacinolone
Budesonide
- Asthma & COPD
- inhalant corticosteroids
-
Hydrocortisone
Prednisone
- Asthma & COPD
- Oral Corticosteroid
-
Salmeterol
Formoterol
- Asthma & COPD
- long acting B2 agonist
-
Cromolyn sodium
- Asthma & COPD
- mast cell stabilizer
- block Cl- channels
-
Montelukast
Zafirlukast
- Asthma & COPD
- Leukotriene antagonist
-
Zileuton
- Asthma & COPD
- Lipooxygenase inhibitor
-
Omalizumab
- Asthma & COPD
- anti-IgE antibody
-
Iprotropium
Tiotropium
- mACh inhibitor
- bronchodilator
-
Metoclopramide
Domperidone
- D2 antagonist => increase ACh
- cross BBB
- stimulates GI motility, anti-emetic
-
Prucalopride
Tegaserod
- 5HT4 partial agonist
- stimulates GI motility
-
Bethanechol
- ACh agonist
- stimulates GI motility
-
Erythromycin
- macrolide antibiotic
- mimics motilin
- stimulates GI motility
-
Lubiprostone
- activates Cl- channels in GI
- stimulate GI motility
-
Methylcellulose
Psyllium
bulk forming laxative
-
Bisacodyl
Senna
Castor oil
- stimulant/irritant laxative
- activate cAMP & GMP
- inhibits Na/K ATPase
-
Magnesium hydroxide
Polyethylene Glycol
Lactulose
osmotic laxative
-
Docusate
- surfactant laxative
- stimulate GI fluid and electrolyte secretion
-
Glycerine suppositories
Liquid paraffin
lubricant laxative
-
Ondansetron
- 5HT3 blocker
- anti-emetic (cancer treatment)
-
Granisertron
- 5HT3 blocker
- anti-emetic (cancer treatment)
-
Dolasetron
- 5HT3 blocker
- anti-emetic (cancer treatment)
-
Dronabinol
Nabilone
- cannabinoid receptor agonist
- anti-emetic (cancer treatment)
- stimulates appetite
-
Scopolamine
- Anti-Emetic
- anti-cholinergic
- motion sickness
-
Diphenydramine
Promethazine
- Anti-Emetic
- 1st gen H1 blocker
- motion sickness
-
Aprepitant
- Anti-Emetic
- substance P antagonist
-
Ursodeoxycholic acid (UDCA)
- synthetic bile acid
- treat gall stones
-
-
Pancrealipase
- pancreatic enzyme mixture
- enzyme replacement in chronic pancreatitis (CF)
-
Orlistat
- inhibit pancreatic lipase
- weight loss therapy
-
Latanoprost
Bimatroprost
Travoprost
- Glaucoma
- PGF2a analog
- increase aqueous humor outflow (Glaucoma)
-
Timolol
metipranolol
betaxolol
- Glaucoma
- beta-blockers
- decrease aqueous humor production
-
Apraclonidine
Bromonidine
- Glaucoma
- alpha2-agonist
- Decrease aqueous humor production
- increase aqueous humor outflow
-
Acetazolamide
Dorzolamide
- Glaucoma
- carbonic anhydrase inhibitor
- decrease aqueous humor production
-
Pilocarpine
Carbachol
- Glaucoma
- ACh agonist
- increase aqueous humor outflow
- not for close angle glaucoma
-
Phenytoin
- Anti-Epileptic
- prolong Na channel inactivation
-
Carbamazepine
- Anti-Epileptic
- prolong Na channel inactivation
- increase ADH release
-
Valporate
- Anti-Epileptic
- prolong Na channel inactivation
- inhibits T-type Ca2+ channels
- inhibit GABA transaminase
- inhibit glutamate receptors
-
Zonisamide
- Anti-Epileptic
- prolong Na channel inactivation
- inhibit T-type Ca channel
-
Ethosuximide
- Anti-Epileptic
- inhibit T-type Ca channel
-
Lamotrigine
- Anti-Epileptic
- prolong Na channel inactivation
- inhibit T-type Ca channel
- inhibits glutamate receptor
-
Topiramate
- Anti-Epileptic
- prolong Na channel inactivation
- Potentiate GABA channels
- inhibits AMPA receptor
- carbonic anhydrase inhibitor
-
Gabapentin
Pregabalin
- Anti-Epileptic
- increase GABA release
-
Vigabatrin
- Anti-Epileptic
- inhibit GABA transaminase
-
Tiagabine
- Anti-Epileptic
- inhibit GABA reuptake
-
Levetiracetam
- Anti-Epileptic
- increase GABA
- decrease glutamate
-
Felbamate
- Anti-Epileptic
- inhibit glutamate
- potentiate GABA
-
Imipramine
Desipramine
- Depression treatment
- TCAs
- inhibits NE & Serotonin reuptake
- (also inhibits H1, a1, & M1)
-
Amitriptyline
Nortriptyline
- Depression treatment
- TCAs
- inhibits NE & Serotonin reuptake
- (also inhibits H1, a1, & M1)
-
Clomipramine
- Depression treatment
- TCAs
- inhibits NE & Serotonin reuptake
- (also inhibits H1, a1, & M1)
-
-
-
-
-
-
-
-
-
-
Bupropion
- Depression treatment
- NE & Dopamine reuptake inhibitor
-
Maprotiline
- Depression treatment
- NE reuptake inhibitor
-
Reboxitine
- Depression treatment
- NE reuptake inhibitor
-
Mirtazapine
- Depression treatment
- NE & Serotonin reuptake inhibitor
-
Trazodone
- Depression treatment
- Serotonin reuptake inhibitor (more specific)
-
Nefazodone
- Depression treatment
- Serotonin reuptake inhibitor (more specific)
-
Phenelzine
- Depression treatment
- non-selective MAO inhibitor
-
Tranylcypromine
- Depression treatment
- non-selective MAO inhibitor
-
Moclobemide
- Depression treatment
- reversible MAO-A inhibitor
-
Selegiline
- Depression treatment
- Irreversible MAO-B inhibitor
-
Lithium
- Bipolar treatment
- inhibits phosphoinositides recycling
-
Chlorpromazine
Thioridazine
Trifluoperazine
Fluphenazine
Perphenazine
- anti-psychotic
- block D2, 5HT, a1, M1, H1
-
-
Clozapine
- atypical anti-psychotics
- block D2, 5HT, a1, M1, H1
-
Olanzapine
- atypical anti-psychotics
- block D2, 5HT, a1, M1, H1
-
Risperidone
- atypical anti-psychotics
- block D2, 5HT, a1
-
Ziprasidone
- atypical anti-psychotics
- block D2, 5HT
-
Quetiapine
- atypical anti-psychotics
- block D2, 5HT, a1, H1
-
Aripiprazole
- atypical anti-psychotic
- partial D2 agonist
-
Levodopa
- Parkinson's
- increase CNS dopamine
-
Carbidopa
- Parkinson's
- use with L-Dopa, to prevent peripheral ADCC degradation of L-Dopa
-
Apomorphine
- Parkinson's
- Dopamine agonist
- prevent L-Dopa flucturation
-
Bromocriptine
- Parkinson's
- Dopamine agonist
-
Pramipexole
- Parkinson's
- Dopamine agonist
-
Ropinirole
- Parkinson's
- Dopamine agonist
-
Amantadine
- Parkinson's
- stimulates dopamine release
- inhibit DA reuptake
-
Selegiline
- Parkinson's
- MAO-B inhibitor
-
Rasagiline
- Parkinson's
- MAO-B inhibitor
-
Entacapone
- Parkinson's
- COMT inhibitor
-
Tolcapone
- Parkinson's
- COMT inhibitor
-
Trihexylphenidyl
- Parkinson's
- Anti-cholinergic
-
Benztropine
- Parkinson's
- Anti-cholinergic
-
Reserpine
- Huntington's
- inhibits VMAT - no NE & DA release
-
Tetrabenazine
- Huntington's
- inhibits VMAT - no NE & DA release
-
Anti-Psychotics
- Haloperidol, Fluphenazine, Perphenazine
-
Donepezil
- Alzheimer's
- Cholinesterase inhibitor
-
Galantamine
- Alzheimer's
- Cholinesterase inhibitor
-
Rivastigmine
- Alzheimer's
- Cholinesterase inhibitor
-
Tacrine
- Alzheimer's
- Cholinesterase inhibitor
-
Memantine
- Alzheimer's
- NMDA inhibitor
-
Methylphenidate
- ADHD
- inhibits NE & DA reuptake
-
Amphetamines
- ADHD
- stimulates DA release
- inhibits DA reuptake
- inhibits MAO
-
-
a2-agonist
- Clonidine, Guanfacine
ADHD
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