What is the generic name for Aldomet? dosage strength? indications?
-Methlydopa
-125, 250, 500mg
-intial 250 mg BID - TID
-HTN also for pregnancy
Aldomet (Methyldopa) MOA?
-central alpha 2 agonist, decreases NE
What is the other medication for HTN in pregnancy?
Hydralazine
Coumadin (Warfarin) match color to strength
1mg
2mg
2.5mg
3mg
4mg
pink
lavender
green
brown
blue
Coumadin (Warfarin) match color to strength
5mg
6mg
7.5mg
10mg
peach
teal
yellow
white
What is the generic name for Pradaxa? dosage strength? indications?
Dabigatran
75 mg & 150 mg BID
afib, stroke prophylaxis
Pradaxa (Dabigatran) MOA & impt notes
direct thrombin inhibitor
BEER's list >75 yrs
CrCl >30mL/min 150 mg BID
CrCl < 30mL/min 75 mg BID w/ or w/out food
routine INR not required
Nitroglycerin SL tabs?
0.3, 0.4, 0.6 mg
Nitro-Dur Patches ?
0.1, 0.2, 0.3, 0.4, 0.6, 0.8 mg/hr
Nitrolingual Pump spray?
0.4 mg/metered dose:
200 sprays or 60 sprays
DO NOT SHAKE
Nitro-Bid ointment? strength? important points
2% 0.5 to 2 inches applied in AM and 6hrs later
10-12 hr nitrate free perion
can be used Q8hrs
Mechanism of Action of NTG products?
relaxation of vascular smooth muscle via stimulation of intracellular cGMP
NTG Side effect?
milligram/grain equivalent?
Counseling point?
storage?
most common is HA
0.4 mg = 1/150gr
If, after first SL dose, no improvement or worsening, call 911
original glass container
What is the active long-acting metabolite of Isosorbide Dinitrat?
Isosorbide Mononitrate
Imdur dosage strengths?
How long does it last?
Counseling?
30, 60, 120 mg ER
12 hours
Daily HAs marker of drug activity
APAP relieves nitrate HA w/low risk
Bidil (Isosorbid dinitrate & hydralazine) special indication?
dosage?
Heart failure as an adjunct in self-indentified black patients
20 mg ISDN & 37.5 mg hydralazine, 1-2 TID
Ranexa generic name?
how supplied?
indication?
important notes
Ranolazine ER
500 mg BID (up to 1000 mg BID)
Anti-anginal
metabolized by CYP-450 & WILL NOT abate an acute angina episode, may cause dizziness
Persantine generic name?
How supplied?
indication?
important notes?
Dipyridamole
25, 50, 75 mg
adjunct to coumarin type anticoagulants to inhibit platelet aggregation
orthostasis, GI upset
Aggrenox capsules
How supplied?
Indication?
200 mg ER dipyridamole with 25 mg aspirin
stroke, stroke prophylaxis, TIA
How should Aggrenox be dosed?
What is required for absorption?
What acid is included in the formulation to improve absorption?
Improved antithrombotic action b/c?
Know this drug, commonly used
1 cap BID, morning and evening w/or w/out food
pH<4
tartaric acid
additive antiplatelet effects of both drugs
K-Dur, Klor-Con ER, K-tabs & Micro-K, what dosage strengths are available?
10mEq (750 mg), 20mEq (1500 mg) 15mEq
What can be substituted if pt cannot swallow K-Dur or put it in water?
Klor-Con ER is smaller
KCl 8 mEq
name?
How supplied?
notes?
Klor-Con
600 mg
swallow only
KCl 25 mEq effervescent tabs
name?
How used?
How supplied?
K-Lyte/Cl
place in water and drink
10% (20 mEq/15ml) and 20% (40 mEq/15mL)
IV potassium should NEVER BE GIVEN as a?
bolus
T/F K-Dur can be mixed in water to drink?
True
Name the loop diuretics
Lasix (furosemide)
Bumex (Bumetanide)
Demadex (Torsemide)
Edecrin (ethacrynic acid)
Where do loops work?
MOA?
SE?
Ascending loop
to inhibit Na/K/2Cl cotransport, Na, Cl, & water retained in tubule; loss of Na, K, Mg, & Ca
ototoxicity
What loop can be used if pt has sulfa allergy?
Edecrin (ethacrynic acid)
Recall the strength conversions for loops
Lasix 40 mg = Bumex 1 mg
Lasix 40 mg = Demadex 20 mg
T/F Loops have a ceiling? ie. higher dose no increase in water removal
False. Loops have no ceiling but thiazides do.
Where do thiazides work?
MOA
How supplied?
What mineral/s are loss?
What mineral/s retained?
DCT
inhibits reabsorption of Na & Cl, :. water retained in tubule
