Pharm - Quiz 6

The angine drug _______ is typically administered for ______ because of the first pass effect.

The angine drug nitroglycerin is converted in the active vasodilator molecule ______ by reaction with the amino acid cysteine.

A drug family that is also used to tx angina:

Use of angina drugs has dropped in the last decade due to increased use of ______.

A drug for CHF that causes a positive inotropic effect:

A common The ionic polysacchride anticoagulant that is administered IV:

Nitroglycerin reduces angina by causing primarily (venous/arterial) vasodilation.

Another dug besides nitroglycerin that is metabolized into the active molecule nitric acid:

Two drug families besides organic nitrates that are used to stop angina attacks:

Anticoagulant the blocks vitamin K synthesis:

Anticoagulant that must be given by injection:

Anticoagulant that is teratogenic:

A partially purified anticoagulant whose clotting times are reproducible:

Oral anticoagulants measure their clotting times with a 3 letter abbrev. ___ which stand for _______

If the INR of an anticoagulant is 1, the pt is at a higher risk of (bleeding/clotting/neither).

Names of 2 most commonly RX drugs in the "blockbuster" family that inhibits cholesterol synthesis:

Statin drugs occasionally cause damage to two organs/tissue in the body:

A drug which reduces serum triglycerides (as well as LDL) _______. This drug doesn't reduce the risk of MI/stroke. The lowering of lipids in this case is a _______ outcome which does not produce the desired ______ outcome.

A drug which lowers absorption dietary cholesterol:

Zetia is commonly combined with a stain drug and sold as:

An anticoagulant from pig intestines that is given by injection:

An injection anticoagulant with more reproducible activity than heparin:

An anticoagulant with a very short half life:

The activity of the anticoagulant ________ is measured with an ___ number.

A patient with an INR = 1.2 is at the risk of having (hemorrhage/heart attack).

Drug used to inhibit platelet aggregation:

A naturally ocurring enzyme which dissolves clots:

The most commonly RX generic statin:

Best selling statin drug still under patent:

A drug which inhibits the absorption of dietary cholesterol:

Sales of ____ dropped after a trial which showed that it did not reduce the risk of MI and stroke.

A vitamin which lowers cholesterol when taken in megadoses:

Large doses of NSAIDs may cause ______ of renal a.

NSAIDs are also often used to tx menstrual cramps, medically referred to as:

An OTC NSAID that advertises is lasts the "whole day":

A person with a total/HDL ratio of 10 is at ___ risk of MI and ischemic stroke

A person with a total/HDL ratio of 4 is at _____ risk of MI and ischemic stroke

NSAIDs work at a molecular level by inhibiting the enzyme COX which stand for _______. This enzyme synthesizes the inflammatory molecules:

Celecoxib (Celebrex) claimed to only inhibit the isozyme:

The most common adverse effect of NSAIDs is:

The potent rx NSAID that should not be used for more than 5 days:

Common OTC NSAID with a 6-8 hour half life:

Major advantage of tylenol over other NSAIDs:

A drug that is rx for RA as well as cancer:

An injectable drug that is inhibits tumor necrosis factor that is used for a variety of auto-immune disease: