Mouse Strains

• - Susceptible to autoimmune induced encephalitis
• (multiple sclerosis)

- Retinal degeneration

- High incidence of reticulum cell sarcomas

- Males extremely aggressive

- Susceptible to LDV

- Resistant to ectromelia

retinitis pigmentosa

- Autoimmune diseases similar to human SLE

- Resistant to diet induced atherosclerosis

• Sendai virus
• Resistent to Salmonella enteritidis

TMEV

• Chromosome 16
• Lack T and B cells
• Thymis lymphoma (more in irradiated)

typhlocolitis

mycobacterium

• MEMV
• K virus suckling mice
• Retinal degeneration
• Resistent to Citrobacter rodentium

• Lacks B cells
• Bruton’s tyrosine
• kinase gene affecting signal transduction in B cells
• ↓ B cell #, low IgM, impaired response to polysaccharide antigens
• Human X-linked agammaglobulinemia

- "Follicle very big"

- Most frequently used mouse to superovulate for transgenic egg retrieval

- Retinal degeneration

- Model for rheumatoid arthritis

- High incidence of mammary tumors

- Susceptible to audiogenic seizure

- Dystrophic mineralization of cardiac & skeletal muscle

- Extreme intolerance to morphine and alcohol

Resistent to Salmonella enteritidis

• Mycoplasma pulmonis
• Resistent to M. avium
• Resistent to Salmonella enteritidis
• Preputial gland abscess (Staph. aureus)
• Lyme Dz

• M. avium intracellulare more severe lesions than C3H/HeB/FeJ (LPS unresponsive)
• Selmonella enteritidis

M. avium intracellulare (LPS responsive)

• Giardia muris
• Low incidence of Murine leukemia virus
• Resistent to Salmonella typhimurium

Murine leukemia virus

Resistent to Salmonella enteritidis

• - Retinal degeneration
• - Exocrine pancreatic insufficiency
• - Model for granulomatous autoimmune thyroiditis

• Retinal degeneration (Pde6brd1), blindness by weaning age
• Alopecia areata
• High incidence of mammary tumors
• High incidence of dystrophic mineralization
• High incidence of hepatomas in males
• Susceptible to Ectromelia
• Citrobacter rodentium
• MMTV
• K virus
• Resistant to amyloidosis
• Resistent to MHV
• Skeletal muscle mineralization
• Hepatacellular carcinoma with mets

• Chromosome 13
• NK impared
• Elevated bleeding tendencies

• Cystic endometrial hyperplasia
• Fibrous replacement of bone marrow with estrogen replacement

Reye's syndrome

• -Production of monoclonal antibodies
• -Sensitive to radiation
• -Hypocallosity
• -Low incidence of mammary tumors
• - High incidence of dystrophic mineralization
• - Susceptible to Ectromelia
• Sendai virus
• MHV
• Salmonella typhimurium
• Salmonella enteritidis
• Helicobacter hepaticus: Typhlocolitis
• - Resistant to amyloidosis

• Resistent to mousepox
• Resistent to giardia muris
• Resistent to E. cuniculi
• Resistent to hepatic carcinogenisis
• -Reye’s like syndrome
• Fatty liver

• Bronchioalveolar adenoma
• Myoepitheliomas
• Pregnancy toxemia
• Epicacrdial mineralization
• size of RE system
• Glomerular hylinosis (aged)

• Murine leukemia virus
• LDEV select virus isolates
• E. cuniculi
• Resistent to mousepox
• Glomerular hylinosis
• Thymic lymphoma
• Low incidence of mammary tumors

Helicobacter hepaticus

• Interemediate suspectibility Sendai virus
• Giardia muris
• Helicobacter hepaticus: typhlocolitis
• Resistent Salmonella enteritisdis
• Low incidence Murine leukemia virus
• Pulmonary adenoma
• Lung carcinogenisis

Resistent to Selmonella enteritidis

Intermediate susceptibility Sendai virus

• Ectromelia
• K virus lethal to suckling mice
• MCMV
• MMTV
• Resistent to TMEV
• Resistent to Salmonella enteritidis
• Mast cells in spleen
• Mammary carcinoma
• Primary amyloidosis
• Bronchialveolar adenoma

Sendai virus

• Sendai virus
• Encephalitozoon cuniculi
• Cornebacterium
• Vulvar squamous cell carcinoma3
• Most frequent source for embryonic cells
• Testicular teratomas are common
• Hypocallosity is relatively common
• Prone to mega esophagus and epithelial hyalonosis

• KO stem cells
• teratomas

• - High incidence of micropthalmia, hydrocephalus,
• dermatitis

- Preference for alcohol and sweet tastes

- Reticulum cell sarcomas are common in old mice

- Resistant to ectromelia

- Resistant to irradiation

• T-cell deficient C’some 11
• Transcription factor controlling thymic epithelial cell differentiation
• Athymic/hairless (unrelated but linked)
• Tumor & xenograft studies

• T & B- cell deficient C’some 16
• DNA-dependent kinase, recombines gene segments coding for T (TcR) & B (Ig) cell receptors
• No T cell fxns, hypoplastic lymphoid tissues, No Ig /T cell responses, sensitive to ionizing radiation (defective DNA break repair)
• V(D)J recombination studies, Tumor & xenograft transplantation, lymph subset transfer, reconstitution of human hematopoietic system (Hu-PBL-SCID)

• T & B cell deficient
• C’some 2p
• Recombinase enzymes, prevents formation of functional B α (Ig) & T (TcR) cell receptors
• Hypoplastic lymphoid tissues, no Ig or T cell
• responses
• V(D)J recombination studies, Tumor & xenograft transplantation, lymph subset transfer

• Lack T & NK cells
• Recessive mutation C’some 6
• Phosphatase, impaired signal transduction from cell receptors
• Def humoral/cellular immunity, lack cytotoxic T & NK cells, moth-eaten pelage 2⁰ to folliculitis, autoimmune syndromes, hypergammaglobulinemia
• Apoptosis studies, Autoimmune syndromes

• NK cell deficient
• C’some 13
• Mutation on c’some 13, affects pigment granules (coat, retina), & lysosomal granules of type II pneumocytes, mast cells, & NK cells
• Diluted coat color, lysosomal storage DZ, impaired chemotaxis, bactericidal activity of neuts, ↓NK activity
• Chediak-Higashi syndrome, crossed onto nude or SCID for multiple immune defs

• Impaired apoptosis from Fas (1 pr) or Fas ligand (gld) defect
• Generalized lymphoproliferative DZ (gld), autoimmunity, immunodeficiency
• Apoptosis studies, Autoimmune syndromes

• Genetically engineered disruption of cytokine
• Anemia (IL-2), wasting (IL-2, IL-10), & IBD (IL-2 & IL-10) when housed conventionally
• Physiological role of cytokines in immune response & inflammation

• Genetically engineered disruption of receptor gene
• Lack functional response to signal of interest, variable immune compromise, IBD common in TcR
• KO
• Physiological role of receptors in immune response & inflammation