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What is the difference between pharmacokinetics and pharmacodynamics?
Pharmacokinetics: what the body does to the drug
Pharmacodynamics: what the drug does the the body
Define ADME
Absorption
Distribution
Metabolism
Elimination
Define absorption
All processes from the site of administration to the site of measurement
Define distribution
Reversible transfer of substance between site of measurement and other sites within the body
Define metabolism
Irreversible loss of unchanged substance by chemical conversion
Define elimination
Irreversible loss of unchanged substance from the site of measurement
Define excretion
Irreversible loss of unchanged substance from the body
Define disposition
Elimination and distribution
Pharmacokinetic behaviour is a function of...
Physicochemical and structural properties of a drug
Dosage form
Route of administration
Physiology/anatomy of the body
Pharmacokinetics is influenced by...
Genetics
Size
Age
Disease
Other drugs
Environmental factors
Name the four types of metabolism a drug can undergo and state which phase of reactions it belongs to
Phase I:
Oxidation
Reduction
Hydrolysis
Phase II:
Conjugation
Which three functional groups do we need to be concerned with?
OH
CO2H
NH2
Which is the main phase I reaction
Oxidation
Where does oxidation occur?
C hydroxylations: aromatic or aliphatic Cs
C cleavage: loss of alkyl, amino etc
N or S oxidations
Where does reduction act?
Nitro and keto groups
Where does hydrolysis act?
Ester and amide groups
Phase II reactions and their functional groups
Glucuronidation -OH -CO2H -NH2
Sulphation -OH
Glycine conjugation - CO2H
Acetylation -NH2
Author
laurajane.price
ID
20224
Card Set
drugmetabolism
Description
Drug Metabolism and Disposition cards
Updated
2010-05-21T22:28:11Z
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