Pharm - Quiz 5

  1. Simplified models of clinical depression suggest that depression may result from (high/low) levels of one or more of what neurotransmitters?

    • Dopamine
    • Norepinephrine
    • Serotonin
  2. What are 2 SSRI's other than fluoxetine (Prozac)
    paroxetine (Paxil)

    sertraline (Zoloft)
  3. What family of antidepressants have the adverse effect of sedation and weight gain?
    tricyclic antidepressants (TCA's)
  4. What family of antidepressants have agitation and insomnia as common adverse effects?
    selective serotonin reuptake inhibitors (SSRI's)
  5. What family of antidepressants require major dietary restrictions?
    monamine oxidase inhibitors
  6. What family of antidepressants has increased incidence of suicide over placebo among young (18-25) patients?
    selective serotonin reuptake inhibitors (SSRI's)
  7. Which antidepressant claims to have fewer sexual side effects?
    bupropion (Wellbutrin)
  8. Which antidepressant is also approved for diabetic neuropathy?
    duloxetine (Cymbalta)
  9. Which antidepressant is a SARI that was Rx to Mr. Black on OD America?
    trazadone (Desyrel)
  10. What is the original drug for Tx bipolar disorder?
    lithium carbonate
  11. What are 2 drug families seeing increased use in Tx bipolar disorder?
    anti-seizure meds

    atypical antipsychotics
  12. (T/F) Antidepressant efficacy usually is evident w/i a day or two of starting the drug.
  13. (T/F) SSRI's are often used to treat GAD and OCD.
  14. What is a diuretic most commonly used to TX hypertension?
  15. What diuretic is commonly used to Tx CHF?
  16. What is a common symptom of hypokalemia?
    M. cramping and weakness
  17. A potassium sparing diuretic ______ works on the ______ portion of the kidney nephron.
    • spironolactone¬†
    • distal convoluted tubule
  18. What is the most commonly prescribed ACE inhibitor?
  19. What is the most common adverse effect of ACE inhibitors?
    Persistant dry cough
  20. Generic names of the drug family related to ACE inhibitors that do cause dry cough all end in____.
  21. (T/F) Dihydropyridine calcium channel blockers such as nifeldipine work on the SA node of the heart as well as the vascular smooth m. (VSM)
  22. What antihypertensive drug has seen much less use recently because it does reduce the risk of heart attack and stroke. 
  23. Amlodipin (Norvasc) is a member of the ______ family of antihypertensives.
    Calcium channel blockers
  24. NDRI stands for:
    norepinephrine - dopamine reuptake inhibitor
  25. The only common NDRI (bupropion) is used for _____ as well as depression and claims fewer sexual side effects.
    smoking cessation
  26. The use of MAO inhibitors for depression is negligible because:
    dietary restrictions
  27. Two common tricyclics:
    • amitriptyline (Elavil)
    • imipramine (Tofranil)
  28. SSRI's cause:
    • insomnia
    • agitation
    • weight lose
  29. Lithium carbonate has a ____ TI.
  30. Lamotrigene was FDA approved for
    • seizures
    • bipolar
  31. H_______ work on the ______ and f_______ works on the _______.
    • hydrochlorothiazide - early distal convoluted tubule
    • furosemide - descending loop of henle
  32. The most common adverse effect of diuretics is loss of ____ ion resulting in ______.
    • potassium
    • hypokalemia
  33. A clinical symptom of hypokalemia is:
    m. cramps
  34. ACE stand for:
    angiotensin converting enzyme
  35. What's the most common ACE inhibitor?
  36. What is the most commonly RX calcium channel blocker?
  37. What are 2 non-dihydropyridine CA channel blockers that slow HR and cause vasodilation?
    • dilitiazem
    • verapamil
  38. What is the most potent common diuretic that works on the ascending loop of Henle?
    furosemide (Lasix)
  39. What family of drugs have generic names ending in -sartan?
    angiotensin II blockers

    no cough
  40. Potassium sparing diuretics that are also used to decrease hair growth in trans gender females:

    • Dont help with hair:
    • triamterene
  41. The potassium sparing diuretics work on the _________ portion of the kidney nephron and (are/are not) effective diuretics by themselves. 
    • late distal convoluting tube
    • are not
  42. _____ is a condition where a pregnant woman has a hypertensive crises due to a reaction against her fetus.

    use: labetalol
  43. What hypertensive family is teratogenic?
  44. What antihypertensive drug family ends in -pril?
    ACE inhibitors
  45. What antihypertensive family causes edema?
    Ca channel blockers
  46. A specific tricyclic antidepressant:
  47. What SARI antidepressant has sedative properties?
  48. An SNRI that has official approval for Tx of neuropathic pain as well as depression:
  49. A common diuretic that works on the early distal convoluted tubule:
  50. A common more potent diuretic, ______ or ______(trade name) works on the _________ portion of the kidney nephron.
    • furosemide or Lasix
    • ascending loop of Henle
  51. The most common adverse effect of both furosemide and hydrochlorothiazide is loss of ____ causing ______.
    potassium causing hypokalemia
  52. A drug that can reduce potassium loss (and hypokalemia):
  53. The most commonly Rx ACE inhibitor:
  54. All ACE inhibitors have generic names which end in:
  55. A common non-life-threatening adverse effect of ACE inhibitors:
    persistant dry cough
  56. Dry cough can be avoided by taking:
    angiotensin II receptor blocker
  57. The most commonly Rx angiotensin II receptor blocker?
Card Set
Pharm - Quiz 5
Antidepressants and Antihypertensives