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Pharm - Quiz 5
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Simplified models of clinical depression suggest that depression may result from (high/low) levels of one or more of what neurotransmitters?
Low
Dopamine
Norepinephrine
Serotonin
What are 2 SSRI's other than fluoxetine (Prozac)
paroxetine (Paxil)
sertraline (Zoloft)
What family of antidepressants have the adverse effect of sedation and weight gain?
tricyclic antidepressants (TCA's)
What family of antidepressants have agitation and insomnia as common adverse effects?
selective serotonin reuptake inhibitors (SSRI's)
What family of antidepressants require major dietary restrictions?
monamine oxidase inhibitors
What family of antidepressants has increased incidence of suicide over placebo among young (18-25) patients?
selective serotonin reuptake inhibitors (SSRI's)
Which antidepressant claims to have fewer sexual side effects?
bupropion (Wellbutrin)
Which antidepressant is also approved for diabetic neuropathy?
duloxetine (Cymbalta)
Which antidepressant is a SARI that was Rx to Mr. Black on OD America?
trazadone (Desyrel)
What is the original drug for Tx bipolar disorder?
lithium carbonate
What are 2 drug families seeing increased use in Tx bipolar disorder?
anti-seizure meds
atypical antipsychotics
(T/F) Antidepressant efficacy usually is evident w/i a day or two of starting the drug.
True
False
False
(T/F) SSRI's are often used to treat GAD and OCD.
True
False
True
What is a diuretic most commonly used to TX hypertension?
hydrochlorothiazine
What diuretic is commonly used to Tx CHF?
furosemide
What is a common symptom of hypokalemia?
M. cramping and weakness
A potassium sparing diuretic ______ works on the ______ portion of the kidney nephron.
spironolactone
distal convoluted tubule
What is the most commonly prescribed ACE inhibitor?
lisinopril
What is the most common adverse effect of ACE inhibitors?
Persistant dry cough
Generic names of the drug family related to ACE inhibitors that do cause dry cough all end in____.
sartan
(T/F) Dihydropyridine calcium channel blockers such as nifeldipine work on the SA node of the heart as well as the vascular smooth m. (VSM)
True
False
False.
What antihypertensive drug has seen much less use recently because it does reduce the risk of heart attack and stroke.
atenolol
Amlodipin (Norvasc) is a member of the ______ family of antihypertensives.
Calcium channel blockers
NDRI stands for:
norepinephrine - dopamine reuptake inhibitor
The only common NDRI (bupropion) is used for _____ as well as depression and claims fewer sexual side effects.
smoking cessation
The use of MAO inhibitors for depression is negligible because:
dietary restrictions
Two common tricyclics:
amitriptyline (Elavil)
imipramine (Tofranil)
SSRI's cause:
insomnia
agitation
weight lose
Lithium carbonate has a ____ TI.
Low
Lamotrigene was FDA approved for
seizures
bipolar
H_______ work on the ______ and f_______ works on the _______.
hydrochlorothiazide - early distal convoluted tubule
furosemide - descending loop of henle
The most common adverse effect of diuretics is loss of ____ ion resulting in ______.
potassium
hypokalemia
A clinical symptom of hypokalemia is:
m. cramps
ACE stand for:
angiotensin converting enzyme
What's the most common ACE inhibitor?
lisiniopril
What is the most commonly RX calcium channel blocker?
amlodipine
What are 2 non-dihydropyridine CA channel blockers that slow HR and cause vasodilation?
dilitiazem
verapamil
What is the most potent common diuretic that works on the ascending loop of Henle?
furosemide (Lasix)
What family of drugs have generic names ending in -sartan?
angiotensin II blockers
no cough
Potassium sparing diuretics that are also used to decrease hair growth in trans gender females:
spironolactone
Dont help with hair:
triamterene
The potassium sparing diuretics work on the _________ portion of the kidney nephron and (are/are not) effective diuretics by themselves.
late distal convoluting tube
are not
_____ is a condition where a pregnant woman has a hypertensive crises due to a reaction against her fetus.
Pre-eclampsia
use: labetalol
What hypertensive family is teratogenic?
ARB's
What antihypertensive drug family ends in -pril?
ACE inhibitors
What antihypertensive family causes edema?
Ca channel blockers
A specific tricyclic antidepressant:
amitriptyline
What SARI antidepressant has sedative properties?
trazadone
An SNRI that has official approval for Tx of neuropathic pain as well as depression:
Cymbalta
A common diuretic that works on the early distal convoluted tubule:
hydrochlorothiazide
A common more potent diuretic, ______ or ______(trade name) works on the _________ portion of the kidney nephron.
furosemide or Lasix
ascending loop of Henle
The most common adverse effect of both furosemide and hydrochlorothiazide is loss of ____ causing ______.
potassium causing hypokalemia
A drug that can reduce potassium loss (and hypokalemia):
spironolactone
The most commonly Rx ACE inhibitor:
lisinopril
All ACE inhibitors have generic names which end in:
-pril
A common non-life-threatening adverse effect of ACE inhibitors:
persistant dry cough
Dry cough can be avoided by taking:
angiotensin II receptor blocker
The most commonly Rx angiotensin II receptor blocker?
losartan
Author
jared.seehawer
ID
200654
Card Set
Pharm - Quiz 5
Description
Antidepressants and Antihypertensives
Updated
2013-02-15T03:23:56Z
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