Common Causes: Cancer treatment, Damage to the bone marrow by miscellaneous drugs or toxins, 80% of hospitalized alcoholics mild thrombocytopenia, Vitamin B12 and Folic Acid deficiency, autoimmune diseases, leukemias.
A bacterial infection of the blood
Acute blood loss, infections, inflammation
Makes the body system avoid excessive blood flow.
People without Vitamin K prone to excessive bleeding and bruising.
Group 2 (2,7,9,10)
Refers to a group of bleeding disorders in which it takes a long time for a blood clot to form.
DVT, PE, Strokes, and Heart attacks
Low natural anticoagulants activity (ATIII, Protein C)
Usually auto antibodies directed against plasma coagulation proteins.
Can have specificity against a specific protein or non-specificity against multiple different proteins.
Factor VIII inhibitors
Term used for venous thrombosis of upper and lower extremities associated with: visceral cancer.
Artificial DNA sequence resulting from the combining 2 other DNA sequences in a plasmid.
Non-specific anti-phospholipid antibodies. Found in 10% SLE
Associated: HIV, Medications, Cancers
Directed against plasma coagulation proteins.
vWF proteins are normally broken down into smaller, inactive fragments by an enzyme.
Deficiency: accumulation of vWF multimers (Abnormally large vWF molecules)
Causes: Genetic, others acquired
Synthesized by megakaryocytes and vascular endothelium
95% of Factor VIII composed of vWF
Stabilizes Factor VIII and promotes platelet adhesion
Types of clotting disease
Coumadin (warfarin) therapy
EffectsGroup 2 (2,7,9,10) because it's a Vitamin K inhibitor.