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Isosteres

  1. Ketone substitute
    • 1. Sulfoxide
    • 2. Sulfone
    • 3. Oxime
  2. Carboxylic acid substitute (and pKa)
    pKa ~ 4.7

    • 1. Sulfonamide
    • 2. Tetrazole
  3. Amide substitute
    • 1. Ketone (replace N with C)
    • 2. Alcohol (replace N with C)
    • 3. Carbamate
  4. Benzene
    • 1. Pyridine
    • 2. Imidazole
    • 3. Furan
    • 4. Thiazole
  5. Sulfoxide
    R-S(=O)-R'
  6. Sulfone
    R-S(=O)2-R'
  7. Oxime
    R-C(=N-OH)-R'
  8. Sulfonamide
    R-S(=O)2-NH-R'
  9. Tetrazole
    R-C-NH-N=N-N=N-C(ring)
  10. Carbamate
    R-O-C(=O)-N-R'
  11. Pyridine
    (RING)-C=C-C=C-C=N-(RING)
  12. Imidazole
    (RING)-C=C-NH-C=N-(RING)
  13. Furan
    (RING)-C=C-O-C=C-(RING)
  14. Thiazole
    (RING)-C=C-S-C=N-(RING)
  15. Hydrogen
    Fluorine
Author
kohaa
ID
200145
Card Set
Isosteres
Description
Non-classical Isosteres
Updated

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