Med Chem III Exam #1

  1. Azoles
    appears to inhibit fungal CYP450 enzymes responsible for fungal sterol biosynthesis, lanosterol 14 alpha-demethylase
  2. Allylamines
    inhibits squalene 2,3-epoxidase in the ergosterol pathway which leads to the buildup of squalene damaging cell membranes
  3. Polyenes
    appear to bind cell wall sterols leading to disruption of the membrane and loss of K+
  4. Griseofulvin
    binds tubulin dimer and prevents microtubule formation by causing dissolution of mitotic spindle apparatus leading to arrest of cell division
  5. Phenol and derivatives
    acts on cell membranes and blocks amino acid transport into cell
  6. Fatty acids
    disruption of cell membranes
  7. Nucleoside -- Flucytosine
    incorporated in RNA, deaminated to 5-fluorouracil leading to inhibition of thymidylate synthetase
  8. Glucan synthesis inhibitors
    inhibit the synthesis of beta (1,3)-D-glucan an integral component of the fungal cell wall
  9. Gentian violet
    disruption of cell walls
  10. Hlaoprogin – Halotex
    inhibit DNA replication
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Med Chem III Exam #1
Med Chem III Exam #1 moa