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jcu1
on FreezingBlue Flashcards.
-
bloom strength
measure of gel rigidity
-
hydroxypropyl methylcellose
- vegetable
- low moisture content
- more soluble
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components of softgel manufacturing
- 1. gel mass
- 2. fill formation
- 3. encapsulation
- 4. drying
- 5. finishing
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gell mass (shell formation) - what are the shells made of?
- gelatin: animal skin and bones
- plasticizers: water, glycerin, sorbitol, partially dehydrated sorbitol, propylen glycol, mannitol
- water
- colorants, flavors, sweeteners, preservatives
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tests performed on gelatin
- bloom test
- iron content
- viscosity
- microbiology
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plasticizers - what they do
- reduce the glass transition temp
- reduce protein-protein interactions
- increase protein chain motility
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plasticizer examples
- glycerin - low MW, high hygroscopicity, low Tg
- sorbitol
- matitiol
- low MW PEGs
-
colorant examples
- dyes: water soluble
- lakes: insoluble forms of a dye
- in organic pigments (titanium dioxide)
- natural colorants (riboflavin)
-
opacifier examples
- titanium dioxide
- light resistant
- used for things with an unaesthetic fill
- 0.5-1% by weight of shell
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things that cause crosslinking
- high temp, humidity
- UV and gamma radiation
- rapid drying
- aldehydes, ketones
- imines, carbodiimides
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hydrophilic vehicles for softgel capsules
- PEGs of low MW's
- MPEGs (methoxy-PEGs)
- glycofurol
- ethyl alcohol (may diffuse and carry out other fill components)
- water, glycerine, propylene glycol (may act as a plasticizer for the shell)
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lipophilic vehicles for softgel capsules
- free fatty acids
- ethyl alcohol
- propylene glycol
- glycerin
- sorbitol/sucrose
- polyethoxylated fatty acid esters
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drying the softgel capsules
- primary drying - tumbler drying
- secondary drying - tray drying process
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