med chem III test I

retapamulin
50s interaction, protein L3 & P site
dermatological use only
metabolized by CYP3A4
ind - impetigo caused by MRSA

macrolide
inhibits RNA polymerase
oral for C. Diff
not for systemic absorption
substrates of efflux & P-glycoprotein

4 beta-lactam antibiotics groups