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What blood preservative solutions expire in 21 Days?
- ACD (Acid citrate dextrose)
- CPD (Citrate phosphate dextrose)
- CP2D (double dose)
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What blood preservative solutions expire in 35 days?
CPDA-1
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WHAT BLOOD PRESERVATIVE SOLUTIONS EXPIRE IN 42 DAYS?
- AS-1 (CPD + BAXTER)
- AS-3 (CPD + PALL)
- AS-5 (CPD+ TERUMO)
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Whole Blood Storage, Stability, & hct are what?
- 1-6 oC
- shelf life depends on anticoagulant in bag
- Hct is 30-40%
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Whole Blood less than 7 days old should be used for who?
Neonates
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RBC's (made by removing plasma from WB). What is the storage & hct level
- 1-6C
- hct should not exceed 80%
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Shelf life can increase to 42 days with AS-1,3, or 5 for what type of collection only?
RBC's ONLY!
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When AS 1,3, or 5 is used, how much is added and what is the hct?
- 100 - 110mL's added
- hct is 55%-60%
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The presence of leukocytes in blood is associated with what types of reactions?
- Allommunication to HLA's
- Refractoriness to platelet transfusions
- Nonhemolytic Febril
- TRALI
- Disease transmission (CMV,HTLV,EBV)
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AABB standards require that leukoredction must reduce the leukocytes to what and in how many units? How much origional RBC's must remain?
- <5x106 per unit in 95% of units tested.
- 85% of the origional RBC's must remain.
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How can you leukoreduce?
- Bedside filtration
- prestorage filtration
- centrigugation
- Saline washing
- freeze and deglycerolize
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What decreases upon storage of RBC's?
2,3-DPG
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If RBC's are preserved with CPD or CPDA-1,h ow can you raise the levels of 2,3-DPG & ATP in RBC's?
- By adding a solution containing:
- pyruvate, inosine,adenine & phosphate.
Process can occur up to 3 days following expiration date of origional unit of RBC's
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How long are Rejuvinated RBC's stable?
24 hours
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Whole Blood Derived Platelets are very unstable at what pH?
below 6.0 they become irreversible
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What are the AABB standars for Whole Blood Derived Platelets?
- > 5.5 x 1010 platelets
- pH > 6.2 at the end of allowable storage
- must occur in 90% of the units
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Platelets are stored how?
- with continual agitation for 5 days
- at 20 -24C
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Platelet packs pooled from WB in 6-8packs expiration date is what?
4 hours
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What are the AABB standards for Platelet Pheresis?
At least 90% of units must:
- Contain > 3.0x1011 platelets
- at the end of allowable storage or time of issue, have a
- pH of > 6.2
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What are the AABB standards for leukoreduced Platelets derived from WB?
8.3x105 leukocytes in 95% of the units tested.
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What are the AABB standards for leukoreduced platelets collected by apheresis and WB derived?
- Must contain:
- <5x106 leukocytes in 95% of units tested
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What are washed platelets useful for & when does it expire
- IgA deficient patient (patient who developed anti IgA
- Expires in 4 hours
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What does Plasma contain
Fibrinogen & Prothrombin
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Cryoprecipitate (reduced plasma) contains what?
Albumin,factors: II,VIVII,IX,X,XI, & ADAMTS13
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What is Cryoprecipitated AHF or Cryo?
- Is the cold insouble precipitate recovered from a controlled thaw of FFP.
- Can be prepared from FFP anytime during 12 months of storage
- It is the white material that remains
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Cryo is suspended in 15mL of plasma and frozen withing 1 hour. How long is it stable and what temp is it frozen?
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What are the AABB standards for Cryo?
- Must contain:
- > 80 lU per unit of Factor VIII
- Fibrinogen levels must be > 150 mg/unit
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What are the AABB standards for Granulocytes?
- Must contain a minimum of:
- 1.0x1010 granulocytes in at least 75% of the units tested
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