Hematology Ch. 16

  1. Lymphocytes and plasma cells are responsible for:
    • Recognition of foreign antigens
    • Antibody protection
  2. Lymphocytes originate from:
    Stem Cells in bone marrow
  3. B-lymphs responsible for:
    Antibody synthesis
  4. T-lymphs responsible for:
    Antigen recognition
  5. Bone marrow and thymus gland are known as the __________ Lymphoid tissues.
  6. Lymph nodes, spleen, Peyer's Patch are known as ___________ Lymphoid tissues.
  7. Lymphocyte recirculation:
    Lymphs move freely between peripheral blood and lymphoid tissues.
  8. Image Upload 1
  9. Image Upload 2
  10. Only ____________ lymphocytes are normally seen in peripheral blood.
  11. Most "small" lymphs are ____ lymphs.
  12. Most "large" lymphs are _____ lymphs
  13. T or F. The Wright Stain can accurately differentiate between T and B lymphs.
  14. _____% of peripheral lymphocytes may be morphologically abnormal
  15. Variant Lymphocytes have been immunologically stimulated and have _________ DNA/RNA activity.
  16. They are associated with viral infections, such as:
    IM, viral pneumonia, and hepatitis
  17. General characteristics of Variant Lymphocytes:
    • Large overall size.
    • Large, irregular (oval, lobulated, folded) nucleus
    • Abundant, smooth, light gray to dark blue cytoplasm.
    • "Sticky" often have adjacent RBCs.
    • Peripheral basophilia
    • Vacuoles and azurophilic granules may be present.
  18. Image Upload 3
    Atypical lymphocyte
  19. Bi-nucleated lymphocytes are associated with:
  20. Rieder cells (clover leaf nuclei) are associated with:
  21. Vacuolated lymphs are associated with:
    • Viral infection
    • Chemotherapy
    • Irradiation
  22. Smudge cells (broken cells) are associated with:
    CLL, artifact
  23. T-Lymphs (cellular immunity) functions and membrane characteristics:
    Antigen recognition and B-lymph regulation
  24. B-lymphs (Humoral immunity) are associated with:
    • Antibody production
    • A mature, activated B-lymph is a plasma cell
  25. NK
    • Cytotoxic reactions
    • Stimulated by interferon and kill virus infected cells
  26. K-type lymphocytes
    Kill cells coated with IgG antibody
  27. Lymphs have specific receptor sites on their membranes that:
    Regulate their immune responses
  28. These various receptor sites are used to:
    classify the various lymph subgroups
  29. T-lymphs are classified into 2 subgroups:
    • Suppresor/Cytotoxic (CD8)=inhibits B-lymph activity.
    • Helper/Inducer (CD4)=Stimulated B-lymph activity
  30. What is the normal helper/suppressor ration?
    • 2:1
    • It is utilized to evaluate HIV patients.
  31. A helper/suppressor=0.5 indicates:
    poor immune status
  32. Plasma cells are mature, stimulated B-lymphs, actively synthesizing antibody.
    Plasma cells should be ID as plasma cells on the WBC differential
  33. Plasma cell development:
    • B lymph (creates antibodies)
    •         Blast Transformation
    •         Antigenic stimulation
    •         T-Helper Cell Stimulation
    • Plasma Cell
  34. Plasma Cell characterisitics:
    • Large cell
    • Large, dark blue, condensed, eccentric nucleus.
    • Basophilic cytoplasm
    • Perinuclear halo (light area around nucleus)
  35. Image Upload 4
    Plasma Cell
  36. Image Upload 5
    Plasma Cell
  37. Image Upload 6
    Plasma Cell
Card Set
Hematology Ch. 16