Flouroquinolones.txt

Home

Get App

Take Quiz

Create

What is the MOA for flouroquinolones?

DNA gyrase inhibitor (Topoisomerase II/IV)
What treats atypical PNA?

flouroquinolones
What types of bacteria does flouroquinolones treat?
- Gram – aerobic (primarily)
- Gram + (newer agents)
Which flouroquinolone is not excreted via renal?

Moxifloxacin
If you give Moxifloxacin, do you need to adjust the dose for a CC<50?

No, not excreted via renal
At what point does the dosage of flouroquinolone need to be adjusted?

CC<50ml/min (except Moxifloxacin)
Does flouroquinolone cross the placenta?

Yes
What pregnancy category is flouroquinolones?

C
What 3 things causes resistance to flouroquinolones?
- Mutations (binding region of target enzyme & change in permeability of the organism)
- Overuse of the agents (staph, strep, and enterococcus developed resistance)
- Cross resistance to other quinolones
When should fluroquinolones be used?

Only when needed
What are fluroquinolones used to treat?
- UTI
- Multi-drug resistant bacteria
- Bacterial diarrhea (salmonella, e. coli)
- Bones, joints, soft-tissues
- Atypical PNA
Are fluroquinolones used to treat gonococcal infections?

No
What is the choice tx/prophylaxis of anthrax?

Fluroquinolones
What are the adverse side effects of fluroquinolones?
- GI
- QT interval prolongation
- Tendon rupture
- Risk for SZ
What 3 things does fluroquinolones have a Black Box warning on?
- Myasthenia gravis
- Tendonitis
- Tendon rupture
What Patient group is contraindicated in using fluroquinolones?

<18 years
What kind of drug is Ciprofloxacin?

Fluoroquinolone
What is the MOA of Cipro?

Inhibits DNA replication by binding to DNA gyrase & topoisomerase IV
What does Cipro treat?
- UTI’s
- Gastroenteritis
- Osteomyelitis
- Anthrax
How does Cipro toxicity manifest?
- GI upset
- Neurotoxicity
- Tendonitis

Author

drtrouta

198796

Card Set

Flouroquinolones.txt

Description

Flouroquinolones.txt

Updated

2013-02-08T02:25:40Z