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Antifungal - Amphotericin B .txt

  1. How does Amphotericin B work?
    Forms pores in fungal membranes which contain ergosterol but not in cholesterol-containing membranes
  2. What are the effects of Amphotericin B?
    Loss of intracellular contents through pores (fungicidal)
  3. What are the clinical applications of Amphotericin ?
    • Candidemia
    • Cryptococcus
    • Histoplasma
    • Blastomyces
    • Coccidioides
    • Aspergillus
  4. What kinds of illnesses does Amphotericin B treat?
    • Fungal meningitis (intrathecal)
    • Bladder & ocular infections (topical)
  5. What kind of adverse effects does Amphotericin B have?
    • Renal impairment
    • Liver failure
  6. What kind of macrolide is Amphotericin B?
    Polyene macrolide
  7. Does Amphotericin work in CSF?
    No
  8. What 2 types of adverse effects can occur with Amphotericin?
    Immediate & Delayed
  9. What do we do help with nephrotoxity of Amphotericin B?
    give a pre & post bolus of NS
  10. What kinds of delayed reactions do you see with Amphotericin B?
    renal damage & liver FX abnormality
Author
drtrouta
ID
198790
Card Set
Antifungal - Amphotericin B .txt
Description
Antifungal - Amphotericin B .txt
Updated

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