Antifungal - Allylamine.txt

What's the common name for Terbinafine?

Lamasil
What is Terbinafine?

synthetic allylamine
What is the MOA of Terbinafine?

Inhibits epoxidation of squalene in fungi so increased levels become toxic to them
What is the effect of Terbinafine?

Reduces ergosterol & prevents synthesis of fungal membrane
What does Terbinafine treat?

Mucotaneous fungal infections
What baseline lab do you need to obtain before starting Terbinafine?

LFTs (can be elevated 2-3 x's before need to d/c it)
What are the adverse effects of Terbinafine?

GI upset, HA, & hepatotoxicity

Author

drtrouta

198789

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Antifungal - Allylamine.txt

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Antifungal - Allylamine.txt

Updated

2013-02-08T02:15:21Z

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