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Sean's ANTIFUNGAL

  1. WHAT CLASS OF ANTIFUNGAL IS AMPHOTERICIN B?
    POLYENE MACROLIDE
  2. WHAT IS THE MOA OF AMPHOTERICIN B?
    FORMS PORES IN THE FUNGAL MEMBRANE BUT NOT IN MAMMALIAN MEMBRANES. IT DOES THIS BY BINDING ERGOSTEROL
  3. NAME 2 MAJOR ADVERSE OR TOXIC EFFECTS OF AMPHOTERICIN B?
    • RENAL IMPAIRMENT
    • LIVER FAILURE
  4. WHAT IS THE SIGNIFICANCE OF THE LIPID FORMULATION OF AMPHOTERICIN B?
    HAS A LOWER TOXICITY WHICH ALLOWS FOR A HIGHER TO DOSE TO BE GIVEN
  5. WHAT CLASS OF ANTIFUNGAL IS FLUCYTOSINE?
    PYRIMIDINE ANALOGUE
  6. WHAT IS THE MOA OF FLUCYTOSINE?
    INTERFERES WITH THE DNA AND RNA SYNTHESIS IN THE FUNGUS
  7. NAME 2 MAJOR TOXICITY ASSOCIATED WITH FLUCYTOSINE?
    • TOXIC ENTEROCOLITIS
    • MYELOSUPPRESSION WHICH CAN CAUSE LEUKOPENIA AND THROMBOCYTOPENIA
  8. WHAT ANTI-CANCER MEDICATION IS FLUCYTOSINE RELATED TO?
    5-FU
  9. REGARDING CHEMISTRY, WHAT ARE 2 TYPES OF AZOLES?
    • IMIDAZOLES
    • TRIAZOLES
  10. WHAT IS THE MOA OF THE AZOLES?
    Reduction of ergosterol synthesis by inhibition of fungal cytochrome P450 enzymes
  11. NAME 2 SIDE EFFECTS OF THE AZOLES?
    • (RELATIVELY NONTOXIC)
    • GI UPSET
    • LIVER ENZYME ABNORMALITY
  12. NAME THE AZOLE THAT IS NOT ELIMINATED BY THE LIVER?
    FLUCONAZOLE
  13. NAME 3 AZOLES WITH HIGH ABSORPTION?
    • FLUCONAZOLE
    • VORICONAZOLE
    • POSACONAZOLE
  14. NAME A MAJOR INDICATION FOR THE USE OF FLUCONAZOLE? WHY?
    • FUNGAL MENINGITIS
    • GOOD CSF PENETRATION
  15. THESE ANTIFUNGALS ARE DESCRIBED AS LARGE CYCLIC PEPTIDES LINKED TO LONG-CHAIN FATTY ACIDS?
    ECHINOCANDINS
  16. NAME 2 KINDS OF ECHINOCANDINS?
    • CASPOFUNGIN
    • MICAFUNGIN
  17. WHAT IS THE ONLY ROUTE OF ADMINISTRATION FOR THE ECHINOCANDINS?
    IV ONLY
  18. WHAT TYPE OF ORGAIN IMPAIRMENT WOULD REQUIRE DOSE ADJUSTMENT OF THE ECHINOCANDINS?
    LIVER IMPAIRMENT
  19. WHAT IS THE MOA OF THE ECHINOCANDINS?
    ACTS ON THE FUNGAL CELL WALL TO INHIBIT B-GLUCAN
  20. NAME 2 ADVERSE EFFECTS FOR THE ECHINOCANDINS.
    MINOR GI UPSETS & FLUSHING
  21. NAME 2 MEDICATIONS THAT MICOFUNGIN CAN INCREASE THE LEVELS OF.
    • NIFEDIPINE
    • CYCLOSPORIN
  22. NAME 3 CONDITIONS THAT THE ECHINOCANDINS ARE USED FOR.
    • DISSEMINATED CANDIDA INFECTIONS
    • PROPHYLAXIS IN BONE MARROW TRANSPLANT
    • CANDIDEMIA
  23. THIS TYPE OF ANTIFUNGAL INHIBITS FUNGAL ENZYME SQUALENE EPOXIDASE, INTERFERES WITH ERGOSTEROL SYNTHESIS AND ARE HIGHLY LIPOPHILIC?
    ALLYLAMINES
  24. NAME A COMMON MEDICATION THAT IS AN ALLYLAMINE?
    TERBINAFINE (LAMISIL)
  25. NAME 3 ADVERSE EFFECTS OF THE ALLYLAMINES?
    • GI UPSET
    • HA
    • LIVER TOXICITY
  26. WHAT IS THE UPPER LEVEL FOR LIVER ENZYME ELEVATION WITH THE USE OF ALLYLAMINES?
    2-3X ELEVATION ABOVE NORMAL
  27. THIS TYPE OF MEDICATION IS USED TO TREAT DEMATOPHYTOSIS OF THE SKIN, NAILS AND HAIR?
    GRISEOFULVIN
  28. WHAT IS GRISEOFULVIN DERIVED FROM?
    PENICILLIUM
  29. HOW CAN YOU EASILY INCREASE THE ABSORPTION OF GRISEOFULVIN?
    TAKE IT WITH FATTY FOODS
  30. NAME A POLYENE MACROLIDE, LIKE AMPHOTERICIN B, THAT IS USED FOR TOPICAL ANTIFUNGAL THERAPY?
    NYSTATIN
  31. NAME 3 CONDITIONS THAT NYSTATIN IS USED FOR?
    • LOCAL CANDIDA
    • THRUSH
    • RINGWORM
  32. NAME 3 TOPICAL AZOLES THAT CAN BE PURCHASED OVER THE COUNTER AND THEIR INDICATIONS?
    • CLOTRIMAZOLE (VULVOVAGINITIS)
    • MICONAZOLE (TINEA INFECTIONS)
    • KETOCONAZOLE (SEBORRHEIC DERMATITIS)
  33. NAME 2 TOPICAL OTC ALLYLAMINES AND THEIR INDICATIONS.
    • TERBINAFINE & NAFTIFINE
    • TINEA CRURIS AND TINEA CORPORIS
Author
drtrouta
ID
198752
Card Set
Sean's ANTIFUNGAL
Description
Sean's ANTIFUNGAL
Updated

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