BIO 116 Ch. 12

NOPE

YES

SHIV - Simian-Human Immunodeficiency Virus

they are injected with B and T lymphocytes so they can be infected with HIV for testing

HIV keeps fucking mutating and evading the immune system

yes, but only really in monkeys

Humoral (antibodies) and cell mediated (T cell)

viruses that are designed to not cause infection but can stimulate immune response.

• 1) best method for delivery to body
• 2) what are the side effects
• 3) is the compound effective
• 4) is the compound MORE effective than current drugs

uninfected people are tested to determine the side effects and safety of the drug, and also determine the most effective delivery and dosage

small # of HIV+ people are given the drug to evaluate the effectiveness (efficacy) by a reduction in symptoms, reduction in measured viral infection, or an increase in immune function

many HIV+ people participate in efficacy studies conducted in many different locations. Once the drug passes this phase, the drug can be approved by the FDA.

keep improving them!

blocks entry after HIV has bound to the target cell

bind to viral RNA and may lead to the destruction of the new complex

cut viral RNA thus inactivating any further activity

stems cells and bone marrow transplants

opportunistic infections!

created opportunities for administration of experimental drugs by local physicians

a way for patients that live too far away from a research hospital to participate through their individual doctor

for diseases that take year to develop, alternate endpoints are decided on to determine effectiveness (with HIV, if the patient developed HIV antibodies)

• understanding about prevention
• understanding and compassion

• education and prevention
• developing drugs agains HIV

we have time on our side because HIV takes a shitload of time to develop