Antibiotics part 2

bactericidal by preventing protein synthesis by binding to 30s ribosomal subunit

• gram-negative bacteria
• ~Pseudomonas spp., E. coli, Proteus spp., Klebsiella spp., Serratia spp. 

• known drug allergy
• pregnancy categories are from C to D

• nephrotoxicity, ototoxicity
• headache, paresthesia, fever, superinfection, vertigo, skin rash, dizziness

risk for nephrotoxicity can be increased with concurrence use of other nephrotoxic drugs

Bactericidal by altering bacterial DNA

• UTI- complex
• Respiratory infections, bone and joint infections, GI and skin infections, STD
• Anthrax

known drug allergy

• prolonged QT interval
• CNS- headache, dizziness, fatigue, depression, restlessness, insomnia
• GI- nausea, vomiting, diarrhea, constipation, thrush, increased liver function studies
• Integumentary- rash, pruritus, urticarial, flushing, photosensitivity
• Other-Fever, chills, blurred vision, tinnitus
• Black box- tendonitis and tendon rupture

chronic bone infections, GU infections, intraabdominal infections

vancomycin-resistant Enterococcus faecium, hospital-acquired skin and skin structure infections, MRSA

• hypotension,
• serotonin syndrome, tyramine-containing foods

• anaerobic organisms
• intraabdominal and gynecologic infections
• protozoal infections
• severe drug interactions

• primarily used for UTI
• careful if renal function is impaired
• may cause fatal hepatoxicity 

• IV only
• VRE and other complicated skin
• may cause arthralgias, myalgias

• IV only
• treat complicated skin and soft-tissue infections

bactericidal by destroying the cell wall

MRSA- choice treatment

• ototoxicity and nephrotocixity
• Red man syndrome
• hypotension with rapid infusion

• ensure adequate hydration
• monitor blood leels