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the branch of chemistry dealing with compounds produced by living organisms
- Biochemistry
- Physiological Chemistry
- Biological Chemistry
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involves all the chemical processes of the body that occur in health and disease
- Biochemistry
- Physiological Chemistry
- Biological Chemistry
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derivatives of polyhydroxy alcohols containing an aldehyde or a ketone group (carbonyl group)
carbohydrates
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compounds containing carbon, hydrogen, & oxygen
carbohydrates
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name ending is -ose
carbohydrates
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carbohydrate with an aldehyde group (carbonyl group at end of chain)
Aldose
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carbohydrate with a ketone group (carbonyl group on inner carbon)
Ketose
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starches, sugar, cellulose, glycogen
carbohydrates
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the simplest of carbohydrates
monosaccharides
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these are the building blocks of carbohydrates
monosaccharides
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those monosaccharides that are most important to humans
those with a Hexose formula
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they contain six carbons
those with a Hexose formula
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these are isomers of C6H12O6
those with a Hexose formula
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dextrose, grape sugar, blood sugar
glucose
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levulose, fruit sugar
fructose
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nerve & brain tissue
galactose
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two saccharide groups
disaccharides
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formula - C12H22O11
(2 monosaccharides - H2O)
disaccharides
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cane sugar, table sugar
sucrose
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sucrose is made up of
glucose & fructose
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sucrose upon hydrolysis will yield
glucose & fructose
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maltose is made up of
- glucose & glucose
- (2 molecules of glucose)
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maltose upon hydrolysis will yield
- glucose & glucose
- (2 molecules of glucose)
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lactose is made up of
galactose & glucose
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lactose upon hydrolysis will yield
galactose & glucose
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many saccharide groups
polysaccharides
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the most complex of all carbohydrates
polysaccharides
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glucose, fructose, & galactose
monosaccharides
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sucrose, maltose, & lactose
disaccharides
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starch, glycogen, & cellulose
polysaccharides
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found in plants such as tubers (root) and grains
starch
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the most important polysaccharide to man
starch
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upon complete hydrolysis these will yield glucose molecules
starch
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found as a stored polysaccharide in the liver of man and other animals
glycogen
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this is how our bodies store sugars for later use
glycogen
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found in the make-up of many plants
cellulose (fiber)
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it is not digestible by the human digestive tract so it serves only as a bulking agent
cellulose (fiber)
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splitting apart by water
hydrolysis of carbohydrates
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end products of carbohydrate hydrolysis
monosaccharides
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cannot be further hydrolized
a monosaccharide
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animal metabolism of carbohydrates
oxidation of carbohydrates
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end products are carbon dioxide & water
oxidation of carbohydrates
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the chief source of body energy is the metabolism of carbs
oxidation of carbohydrates
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carbohydrates yield
4 calories per gram
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the opposite of photosynthesis
oxidation of carbohydrates
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the process by which plants convert carbon dioxide, water and solar energy into carbohydrates and oxygen with the presence of the catalyst chlorophyll
photosynthesis
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the anaerobic breakdown of carbohydrates through the action of enzymes produced by microorganisms
fermentation
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glyceryl esters of fatty acids
lipids/fats/oils
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esters of glycerol and fatty acids
lipids/fats/oils
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sometimes called glycerides
lipids/fats/oils
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required elements are the same as carbohydrates - carbon, hydrogen, oxygen
lipids/fats/oils
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required elements are the same as carbohydrates
- carbon, hydrogen, oxygen
- may also contain nitrogen and phosphorus
lipids/fats/oils
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composition of lipids/fats/oils
glycerol & fatty acids
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combined together through esterification (process of making an ester)
glycerol & fatty acids
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they are carboxylic acids Rx-COOH
fatty acids
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if the Rx (carbon chain) is saturated then the lipid is a fat
it's a solid at room temperature
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if the Rx (carbon chain) is unsaturated then the lipid is an oil
it's a liquid at room temperature
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examples of oils
- stearic acid
- palmitic acid
- oleic acid
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end products are carbon dioxide, water, & energy
oxidation of lipids
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lipids are superior to carbohydrates as a source of energy
oxidation of lipids
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they yield 9 calories per gram
oxidation of lipids
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may be stored in the body in unlimited quantities
lipids/fats/oils
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serve to prevent dehydration of body cells
lipids/fats/oils
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serve to insulate the body in terms of heat
lipids/fats/oils
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serve to "cushion" certain body organs
lipids/fats/oils
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end products are glycerol & fatty acids
hydrolysis of lipids
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the alkaline hydrolysis of a fat or oil
saponification of lipids
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the natural process of body decomposition
saponification of lipids
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the alkaline substance used is usually NaOH
saponification of lipids
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the end products of saponification are
glycerol & soap
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the product formed when an alkali such as NaOH reacts with a fatty acid
soap
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when there are calcium containing compounds present at saponification, the end products include
adipocere (grave wax) & glycerol
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the product formed from the saponification of fatty acids in the dead human body by calcium containing compounds
adipocere (grave wax)
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a compound that is wax like in appearance but is chemically more like a soap
adipocere (grave wax)
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a compound whose hydrolytic products are fatty acids and slcohols
simple lipid
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a lipid whose hydrolytic products are fatty acids, an alcohol, and some other ompound
compound lipid
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lipids that are esters of fatty acids and high molecular weight alcohols other than glycerol
waxes
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these are the fundamental constituents of all living matter
proteins
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the building blocks of living things
proteins
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the most complex of the organic compounds, they have extremely large and complex structures
proteins
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required elements: carbon, oxygen, hydrogen, & nitrogen
but may also contain sulfur, phosphorus, iodine, iron
proteins
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made up of amino acids
proteins
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organic or carboxilic acids containing nitrogen
amino acids
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these are the building blocks of proteins
amino acids
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examples of amino acids
- glycine (aminoacetic acid)
- alanine (2-amino propanoic acid)
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long chains of amino acids are known as proteins or polypeptides
amino acids
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maintenance of existing cells
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synthesis (production) of enzymes
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synthesis (production) of hormones
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production of protein components of the blood (such as hemoglobin)
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proteins possess the characteristics of both an acid and a base
amphoteric properties
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this allows them to act as buffers in body metabolism when in solution
amphoteric properties
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maintains pH balance
buffer
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anything that resists change in pH
buffer
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the method by which amino acids are connected to one another
- peptide linkage
- (peptide bond)
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occurs by the dehydration between the carboxyl group (-COOH) of one amino acid and the amino group (-NH2) of another amino acid
- peptide linkage
- (peptide bond)
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long chains of amino acids
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proteins and amino acids have the same properties
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the ability to absorb water
imbibition
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this can lead to the swelling and softening of tissues and organs as a result of the proteins absorbing water from adjacent sources
imbibition
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end products are amino acids
hydrolysis of proteins
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end products are carbon dioxide, water, nitrogenous wastes
oxidation of proteins
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urea, ammonium salts
nitrogenous wastes
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the conversion of complex substances into simpler compounds
catabolism
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the destructive aspect of metabolism
catabolism
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an example is digestion
catabolism
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the processes that build complex substances from simpler compounds
anabolism
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the constructive aspects of metabolism
anabolism
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the storing of glycogen in the liver
anabolism
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2 processes that occur in the metabolism of proteins
- 1. deamination
- 2. decarboxylation
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the process by which the amino group is removed from an amino acid as part of the catabolism (breakdown) of amino acids
deamination
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the amino group removed by this process is converted by the liver into ammonium salts and urea which are highly soluble and may be excreted by the kidneys in urine
deamination
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the simple removal of the carboxyl group from an amino acid as part of the catabolism of amino acids
decarboxylation
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this process leads to the formation of the carbon dioxide and water
decarboxylation
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these 2 processes occur simultaneously during putrefaction
- 1. deamination
- 2. decarboxylation
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decomposition of proteins
putrefaction
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anaerobic oxydation of proteins by bacteria
putrefaction
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end products of putrefaction
- 1. ammonia containing compounds
- 2. Ptomaines such as puprecine & cadavarine
- 3. hydrogen sulfide (H2S)
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formaldehyde reacts with proteins at the _____ bond to denature them
peptide
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the disruption and breakdown of the secondary structure of a protein by heat or chemicals
denaturation
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the effect of formaldehyde on the ____________ ____________ of proteins causes the proteins to coagulate and to become firm
peptide linkages
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the process of forming the insoluble state of a protein by heating or contact with a chemical such as an alcohol or an aldehyde
coagulation
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formaldehyde acts as a ____________ by retarding the decomposition of proteins in a dead human body
preservative
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the ________________ of proteins in a living body is a toxic reaction
denaturing
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____ ___________ ________ _ ______renders the protein useless as a food source to bacteria
the disinfecting effect of formaldehyde
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aids in preserving body proteins
formaldehyde
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the breaking apart of the peptide linkages to form amino acids
decomposition of the body proteins
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if the decomposition of the body proteins has already begun ____?
the amino acids will react with the formaldehyde on a 1 to 1 basis
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the reason for a higher formaldehyde demand on decomposing bodies
the amino acids will react with the formaldehyde on a 1 to 1 basis
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Why should embalming of a dead body be performed as soon as possible?
decomposition of proteins is not reversible
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proteins that act as biological catalysts
enzymes
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alters the speed of a chemical reaction
catalyst
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the substance upon which an enzyme will act
substrate
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each enzyme will act upon only one given substrate
specificity
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carbohydrate enzyme
carbohydrase
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lipid & fat enzyme
lipase
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enzymes that help the human body to self digest as a part of decomposition
autolytic enzymes
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self digestion of the body as a part of decomposition
autolysis
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