week 3

  1. allogenic
    Tissue transplanted from one person to another
  2. alopecia
    hair loss
  3. anti-DNA antibody test
    a blood test that is useful for the diagnosis and follow-up of systemic lupus erythematosus (SLE). The test uses double-stranded deoxyribonucleic acid (DNA) as antigen to detect anti-DNA antibodies. High titers characterize SLE, and low to moderate levels may indicate other rheumatic diseases as well as chronic hepatitis, infectious mononucleosis, and biliary cirrhosis.
  4. antinuclear antibody (ANA)
    An antibody that attacks cell nuclei.
  5. autoantibodies
    an antibody formed in response to, and reacting against, an antigenic constituent of one's own tissues.
  6. antigenic
    having properties of antigen
  7. apheresis
    process in which blood is drawn from a donor, followed by selective separation of one or more constituents and then reinfused back into the body.
  8. arthrocentesis
    the puncture of a joint with a needle and the withdrawal of fluid, performed to obtain samples of synovial fluid for diagnostic purposes
  9. arthroscopy
    examination of a joint, specifically, the inside structures. The procedure is performed by inserting a specifically designed illuminated device (arthroscope) into the joint through a small incision. 
  10. arthroplasty
    surgery to relieve pain and restore range of motion by realigning or reconstructing a joint.
  11. blast cells
    Blood cells in early stage of cellular development
  12. boutonniere's deformity
    flexion of the proximal interphalangeal PIP joint and hyperextension of the DIP, caused by the detachment of the extensor tendon from the middle phalanx, volar displacement and resultant action as a flexor, associated with SLE, rheumatoid arthritis
  13. butterfly (malar) rash
    a skin eruption across the nose and adjacent areas of the cheeks in the pattern of a butterfly, as in lupus erythematosus (50%) 
  14. C-reactive protein CRP
    protein produced by the liver and found in the blood.not normally found in the blood of healthy people. It appears after an injury, infection, or inflammation
  15. contracture
    abnormal shortening of muscle tissue, rendering the muscle highly resistant to passive stretching.
  16. corticosteroids
     class of drugs based on hormones formed in the adrenal gland, used to reduce inflammation. They increase the likelihood of hyperinfection syndrome in patients with threadworm infection.
  17. Distal Interphalangeal (joint) (DIP)
     those between the second and third (distal) phalanges
  18. ecchymosis
    a small hemorrhagic spot in the skin or a mucous membrane, larger than a petechia, forming a nonelevated, rounded, or irregular blue or purplish patch
  19. endocarditis
     infection of endocardium, the inner lining of the heart muscle, which also covers the heart valves
  20. epistaxis
  21. effusion
    escape of a fluid into a part
  22. erythrocyte sedimentation rate (ESR)
    the rate at which erythrocytes sediment from a well-mixed specimen of venous blood, as measured by the distance that the top of a column of erythrocytes falls in a specified time interval under specified conditions.
  23. erythropoiesis
    formation/production of RBCs
  24. exacerbation
    An increase in the severity of a disease or in any of its signs or symptoms.
  25. hematopoiesis
    the normal formation and development of blood cells in the bone marrow
  26. immunosuppression
    the administration of agents that significantly interfere with the ability of the immune system to respond to antigenic stimulation by inhibiting cellular and humoral immunity. It may be deliberate, such as in preparation for bone marrow or other transplantation to prevent rejection by the host of the donor tissue.
  27. lymphadenopathy
    any disorder characterized by a localized or generalized enlargement of the lymph nodes or lymph vessels.
  28. malaise
    a general feeling of discomfort or uneasiness
  29. metacarpophalangeal (joint) MCP
    pertaining to the metacarpal bones of the hand and the phalanges of fingers
  30. DMARDs
    A class of antirheumatic drugs, including chloroquine, methotrexate, cyclosporine, and gold compounds, that influence the disease process itself and do not only treat its symptoms.
  31. metatarsophalangeal joint (MTP)
    Any of the spheroid joints between the heads of the metatarsal bones and the bases of the proximal phalanges of the toes.
  32. myelogenous
    pertaining to the cells produced in bone marrow or the tissue from which such cells originate
  33. neutropenia
    an abnormally low level of neutrophils in the blood
  34. petechia
    numerous tiny purple or red spots appearing on the skin as a result of tiny hemorrhages within the dermal or submucosal layers. Petechiae range from pinpoint to pinhead size and are flush with the surface
  35. pleural effusion
    occurs when too much fluid collects in the pleural space (the space between the two layers of the pleura). It is commonly known as "water on the lungs." It is characterized by shortness of breath, chest pain, gastric discomfort (dyspepsia), and cough.
  36. polyarthralgia
    pain in several joints simultaneously.
  37. polyarthritis
    an inflammation that involves more than one joint. The inflammation may migrate from one joint to another, or there may be simultaneous involvement of two or more joints.
  38. polyarticular
    pertaining to many joints
  39. proximal interphalangeal  (PIP)
    joints between proximal interphalangeal
  40. raynaud's phenomenom
    is a vasospastic disorder causing discoloration of the fingers, toes, and occasionally other areas. This condition can also cause nails to become brittle with longitudinal ridges
  41. Reed-Sternberg cells
    different giant cells found with light microscopy in biopsies from individuals with Hodgkin's lymphoma, usually derived from B lymphocytes
  42. rheumatoid factor (RF)
    an autoantibody (antibody directed against an organism's own tissues) most relevant inrheumatoid arthritis. RF and IgG join to form immune complexes which contribute to the disease process
  43. remission
    the partial or complete disappearance of the clinical and subjective characteristics of a chronic or malignant disease. Remission may be spontaneous or the result of therapy. In some cases remission is permanent, and the disease is cured
  44. sjorgren's syndrome
    a disorder in which the mouth and eyes become extremely dry. Sjögren's syndrome is often associated with other autoimmune disorders
  45. subluxation
    incomplete dislocation of a joint
  46. swan neck deformity
    an abnormal condition of the finger characterized by flexion of the distal interphalangeal joint and hyperextension of the proximal interphalangeal joint. It is caused by a taut profundus tendon in the presence of a weakened distal interphalangeal joint and may be combined with a volar plate rupture. The condition is seen most often in rheumatoid arthritis.
  47. synovitis
    an inflammatory condition of the synovial membrane of a joint as the result of an aseptic wound or a traumatic injury, such as a sprain or severe strain. The knee is most commonly affected. Fluid accumulates around the capsule; the joint is swollen, tender, and painful; and motion is restricted. In most cases, the inflammation subsides and the fluid is resorbed without medical or surgical intervention.
  48. thrombocytopenia
    abnormal drop in number of thrombocytes (platelets)
  49. transplantation
    the transfer of tissue from one site to another or from one person or organism to another.
  50. tumor necrosis factor (TNF)
    either of two lymphokines that cause hemorrhagic necrosis of certain tumor cells but do not affect normal cells; they have been used as experimental anticancer agents. Tumor necrosis factor α (formerly cachectin ) is produced by macrophages, eosinophils, and NK cells. Tumor necrosis factor β, is lymphotoxin
  51. ulnar deviation
    a hand deformity, seen in chronic rheumatoid arthritis and lupus erythematosus, in which swelling of the metacarpophalangeal joints causes the fingers to become displaced to the ulnar side
Card Set
week 3