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Cell Components
- Cell membrane
- Cytoplasmic Organelles
- Nucleus
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Phospholipid bilayer
-Phospholipids arranged with their polar(hydrophilic heads) facing the protein layer and their non-polar (hydrophobic tails) facing eachother.
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Types of cell transport
Active and passive
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Diffusion
Distribution of a substance in a solvent so that it gets equally concentrated
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Simple Diffusion
Down a concentration gradient
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Facilitated Diffusion
Down a concentration gradient but requires a carrier protein (transmembrane protein)
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Osmosis
- -Movement of water across semi-permeable membranes
- -From low to high solute concentration
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Isotonic
- -Solution has the same osmotic pressure.
- -Ex: 0.9% NaCl
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Hypotonic
- -Solution has lower osmotic pressure
- -Less conc. than saline
- -Creates hemolysis (swell) of the cell
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Hypertonic
- -Solution has higher osmotic pressure
- -causes crenation (shrivel) of the cell
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Active Transport
- -Low to high concentration
- -ATP required- Hydrolyzed by ATPase activity of the carrier
- -Phosphorylation of carrier causes change in shape and movement of molecule
- -Changes transmembrane protein
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Example of Active Transport
NA-K ATPase pump
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Components in cytoplasm
- -Cytosol (liquid component)
- -Organelles
- -Cytoskeleton (filaments/microtubules)
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Cell Organelles
- -Endoplasmic Reticulum
- -Mitochondria
- -Ribosomes
- -Lysosomes
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Smooth Endoplasmic Reticulum
- -Found in muscle cell to store calcium
- -Found in endocrine grands and muscle cells
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Rough Endoplasmic Reticulum
- -Protein Synthesis
- -Covered in ribosomes
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Mitochondria
- -Powerhouse of the cell
- -Muscle cells has abundance
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Lysosomes
- -Membrane-bond vesicles that contain hydrolytic enzymes
- -Originate from ER and Golgi
- -Many in WBC...none in RBC-Capable of fusing with intracellular organelles
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Cytoskeleton
- -Microtubules scattered throughout the cytoplasm, largest and most rigid
- -Intermediate Filaments (Cell junction like desmosomes
- -Microfilaments: Spindle fibers during cell division
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Types of Tissue
- -Epithelial (lining)
- -Connective
- -Muscle
- -Nervous
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Classification of Epithelial tissue
- -Simple vs Stratified
- -Squamous(flat), Cuboidal(square), Columnar(tall)
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Location of Simple Squamous
Anmili of the lungs
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Location of Simple Cuboidal
Kidney
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Location of Simple Columnar
Digestive tract
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Location and differences of Pseudostratified Columnar
- -Trachea
- -Not truly stratified
- -Studded with goblet cells which produce mucus
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Location of Stratified Squamous
- -Keratinized is found in the skin
- -Nonkeratinized found in the esophagus
- -Keratinized has glassy feature (close to shedding)
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Location of Stratified Cuboidal
Sweat & salivary glands
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Location of Stratified Columnar
Least common & found in Urethra
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Transitional Tissue
- -Transitions depending on amount of urine in the bladder
- -Tall = full of urine
- -Flat = little urine
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Muscle Tissue
- -Is contractile so it has force and movement
- -Is excitable so can conduct signals
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Connective Tissue
- -Serves to connect other tissues
- -Gives form and strength to organs
- -Loose vs. Dense
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Types of Connective tissue
- -Adipose (fat)
- -Cartilage
- -Bone
- -Blood
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Nervous Tissue
- -Send nervous signals
- -Excitable, electrical, chemical
- -Glial cells support
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Functions of the Skeletal System
- -Support
- -Protection
- -Movement
- -Storage of minerals and lipids
- -Blood cell formation
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Components of Skeletal system
- -Bones
- -Cartilage
- -Teeth
- -Joints
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Living structure of Bones
- -Have blood and lymphatic vessels, nerves
- -Subject to disease
- -Undergo repair
- -Adjust to changes in stress
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Composition of Bone
KTOD
- 45% Inorganic Matter
- -Calcium, Phosphorus
- 30% Organic matter
- Collagen
- 25% Water
- Blood supply
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Bone Structure
- -Compact Bone
- -Cancellous (spongy) Bone
- -Medullary Cavity
- Red marrow vs Yellow Marrow
- -yellow marrow = old animals = fat deposition
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Classification of Bones
- -Long
- -Short
- -Flat
- -Irregular
- -Sesamoid
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Shape of long bone
- -Epiphysis: Ends of the bone (-ses if plural)
- -Diaphysis: Shaft of the bone with surrounds the medullary cavity
- -Articular Cartilage: Cushoins ends of bone & allows for movement
- -Epiphyseal Plate: Areas made of cartilage allowing for growth of the bone
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Function of Long Bones
- -Act as levers
- -Aid in support, locomotion, Prehension
- -Ex: Bones of Extremities
- *Forelimb - Humerus, Radius, Ulna
- *Hindlimb - Femur, Tibia, Fibula
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Short Bones
- -Cube like structure
- -No single marrow cavity
- -Compact bone surface with a cancellous bone center with spaces filled with marrow
- -Ex: Carpals(knee) & Tarsals(hock)
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Function of Short Bones
- -Variety of movements, gliding & sliding
- -Absorb shock/ concussion
- -Found in complex joints
- Ex: Carpus & Tarsus
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Flat Bones
- -No diaphysis or epiphysis
- -Inner framework of cancellous bone sandwiched between compact bone
- -2 plates: Lamina externa & lamina interna
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Function of Flat Bones
- -Protect vital organs:
- Brain(Skull)
- Heart & Lungs (Scapula& Ribs)
- Urinary/ Reproductive organs (Pelvic bones)
- -Provide large areas of attachment of muscles
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Irregular Bones
- -Unpaired bones on the median plane
- -Spongy bone surrounded by compact bone
- -Offer protection, support, and muscular attachment
- Ex: Vertebrae
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Sesamoid Bones
- -Occur along the course of tendons
- -Help in reducing friction, increase leverage or change the direction of pull
- Ex: Patella (Kneecap)
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Visceral Bones
- -Formed in the soft organs
- -Os penis-bone in the penis of dogs
- -Os cordis-bone in the heart of cattle
- -Os rostri-bone in the snout of pigs
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Types of Skeletal Systems
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Axial Skeletal System
- -Includes all the bones of the skull, vertebral column, and rib cage
- -Bones are involved in protection, support, and carrying other body parts
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Vertebral Column
- -Composed of median unpaired irregular bones
- -Vertebra - Body, Arch, and Process
- -Body: Cylindrical mass forming ventral pt & floor of foramen
- -Arch: Completes the foramen
- -Process: Articular/spinous
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Cervical Vertebrae
- -Articular processes allow for range of motion
- -All domestic animals have 7
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Thoracic Vertebrae
- -Well developed spinous processes
- -Costal fovea on adjacent thoracic vertebrae provide articulation with head of ribs
- -Withers of the horse
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Lumbar Vertebrae
- -Larger flat transverse processes provide for more area of attachment
- -Weight bearing vertebrae
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Sacral Vertebrae
- -Fused to form a wedge shaped bone called sacrum
- -Sacral foramina allows passage of spinal nerves
- -Articulates with last lumbar vertebrae cranially
- -Articulates with ilium to the hip
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Axial Skeleton Vertebral Formula
- -CTLSCd (Cervical, Thoracic, Lumbar, Sacral, Caudal)
- -Horse: C7, T18, L6, S5, Cd15-20
- -Cow: C7, T13, L6, S5, Cd18-20
- -Sheep: C7, T13, L6-7, S4, Cd16-18
- -Pig: C7, T14-15, L6-7, S4, Cd20-23
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Ribs
- -Form lateral wall of bony thorax
- -# of pairs of ribs = # of thoracic vertebrae (usually)
- -True ribs aka Sternal ribs are ones attached to sternum by costal cartilage
- -False ribs aka Asternal ribs are caudal to sternal ribs
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Appendicular Skeleton
- -Shoulder (Synarcosis)
- (pectoral girdle-scapula)
- -Fore limbs (Pectoral or Thoracic)
- (Humerus, radius, ulna, carpals, metacarpals, phalanges)
- -Pelvis
- (Pelvic girdle - ilium, ischium, pubis)
- -Hind limbs (pelvic)
- (Femur, tibia, fibula, tarsals, metatarsals, phalanges)
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Forelimb
- -Scapula (shoulder blade)
- -Distal end of spine forms 'acromion process'
- -Humerus
- -Shaft & 2 extremities
- -Proximal end bears a rounded head that articulates with scapula(shoulder joint)
- -Humerus + Scapula = Shoulder Joint
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Forelimb Cont'd
- -Radius & Ulna (Forearm)
- -Radius is larger
- - Ulna forms Olecranon process (point of elbow)
- -Horse; shaft of ulna is fused into radius
- -Ox, Sheep, Goat, Dogs, &Cats; complete ulna
- -Carpus
- -Metacarpus (Cannon)
- -Digits (Fetlock, pastern)
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Os Coxae - Fusion of 3 Bones
- Illium -Largest, dorsal most
- -Tuber sacrale, tuber coxae (point of hip)
- Ischium - Forms the caudal part of the floor of pelvic cavity
- Pubis - Smallest, forms cranial part of the floor
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Hindlimb
- -Femur (Thigh bone)
- -Tibia & Fibula
- -Tarsus
- -Metatarsus
- -Digits
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Organic Components in Bone
- 1.) Bone Cells
- -Osteocytes
- -Osteoblasts
- -Osteoclasts
- 2.)Osteoid
- -Organic part of matrix, collagen, polysaccharides
- -Contributes to resilience & toughness of bones
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Inorganic Components of Bone
- 1.) Calcium & Phosphorus salts (80% is calcium phosphate, rest are calcium carbonate and magnesium phosphate)
- 2.) Provide hardness and rigidity to the bone
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Soft bone
- -Inorganic component removed by soaking in dilute acid
- -Decalcified bone, retains structure
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Brittle Bone
- -Organic component removed by charring
- -Inorganic salts remain
- -Prone to breaking
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Osteoblasts
- -Bone forming cells found in all bone surfaces
- -Synthesize and secrete collagen fibers and other organic components of bone matrix
- -Serve as framework for deposition of Ca & phosphate salts
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Osteocytes
-Mature, nondividing osteoblast surrounded by matrix, lying within lacunae
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Osteoclasts
- -Giant multinucleate cells
- -Responsible for the active erosion of bone minerals
- -Contain large number of mitochondria & lysosomes
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Osteonal System
aka Haversian System
- -Compact bone consists primarily of laminated tubes - Osteonal systems
- -Each osteon consists of a central canal (blood vessels and nerves) surrounded by circular plates of bone (lamellae)
- -Osteons are added on the periphery of the shaft of the bone (increasing diameter)
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