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QG
quantitative genetics - the scientific study of the statistical analysis of the effects that heredity and environment have on phenotypic variation
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2 ways to measure Darwin's step 4
- selection differential (s)
- selection gradient (B) "beta"
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selection differential (s)
- -describes the strength of selection relative to the distribution or variance of the phenotypic trait
- -difference in mean phenotype between the population as a whole and the selected parents of the next generation
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heritability
the proportion of phenotypic variation in a population that is attributable to genetic variation among individuals
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selection gradient (B) "beta"
- the regression slope of "fitness" estimate on phenotype
- used more in ecological studies because it's easier to measure in the field
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selection response (R)
the change in mean phenotype between parental generation before selection, and offspring generation (before selection on it, after selection on parental generation)
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VA
- additive genetic variance
- passed on from parents to offspring, as sum of 2 alleles effects, one from mom, one from dad
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VP
- total phenotypic variance
- S2 phenotypes
- VP = VG + VE
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narrow sense heritability
- h2 = VA / VPh2 = 0,1, or inbetween, if so R<S
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variance (V)
- measure of dispersion about a mean or average
- the standard deviation squared
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VG
- genetic variance
- VG = VA (additive) + VD (dominance - interation between alleles within a gene) + Vi (interaction among genes, gene networks)
- **selection only responds to VA
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Vi
- epistasis
- interaction among genes, gene networks
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Ve
environmental variance
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broad sense heritability
- H2 = VG / VP
- reflects all possible genetic contributions
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locus (plural loci)
the specific location of a gene or DNA sequence on a chromosome
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