Immune System

  1. Innate/Natural Immunity
    • Nonspacific response to a foreign substance:
    • physicial,biochemical,cellular,humoral
  2. Acquired/adaptive Immunity
    • Discriminate between self and nonself.
    • Specific and adaptable
  3. Antigen
    A substance capapable of eliciting an immune response (antibody production).

    typically located on RBC's but can be on WBC's, plt's, & tissue
  4. Antibody/Immunoglobulin
    A protein produced by plasma cells that are specific to antigens.
  5. T Lymps
    T helper aka CD4

    • Can recognize antigens and help B cells evolve into plasma cells.
    • Produces cytokines that result in an inflamatory response
  6. B Lymps
    Mature in Bone marrow

    • Antibody on the B cell membrane is the receptor for specific antigen. 
    •          Evolve into plasma cells that excrete antiody produce memory B cells.
  7. Primary Immune Response
    IgM is produced. the 1st time an individual encounters an antigen and responds.
  8. Lag phase for the primary response
    When there is no detectable antibody 3 - 4 weeks
  9. Anamnestic (secondary) Immune Response
    --------------After presence of memory cells from the primary phase...
    Results in IgG antibody production.

    So, on the second exposure to an antigen memory cells generated in the primary response start this.

    Less antigen is need for this respons.

    Lag phase is hours - 1 to 2 days
  10. Antigenic Determinant/ Epitope
    Is the portion on the antigen that interacts directly with the antibody.
  11. Immunogenicity
    The degree to which an antigen is likely to elicit an immune response.

    Affected by: Size, charge, solubility,complexity,accessability to the antigen, amount of antingen (dose)
  12. Role of Complement
    Red cells will activate comp to C3: Most blood group antibodies are capable of this. Coated RBC's may be removed prematurly from circulation.
Card Set
Immune System
Immune system terms