Lutheran BG System

Home

Get App

Create

What chormosome is the LU locus on and what is it linked to?
- Chromosome 19
- Linked to the SE locus.
What product is produced from the SE locus?

Glycoprotein
At position 77, what does Lu^ashow?

Histidine
At position 77, what does Lu^b show?

Arginine
³here are 3 modes of inheritance for the LU system. Name 1 and a description.

InLu dominant supperssor gene at another locus suppress expression of the Lu antigen. Does not make Anti-Lu3. Other Lu antignes will be extremely weak
What is another mode of inheritiance for the LU system?

X-Linked dominant - which also suppreses the gene. Extremely weak Lu antignes and does not make Anti-Lu3.

similar to the dominant InLu.
What is the final 3rd mode of inheritance for the LU system?

Recessive - The inheritance of 2 recessive null genes at the LU locus. This DOES produce Anti-Lu3 and NO antigens are pressent.
Of Lu^aand Lu^b which is high incidence and which is low.
- Lua is low incidence
- Lub is high incidence - Which means the majority of individual will express this antigen on their RBC's.
Lu^ais what type of antibody?

Typically it is a naturally occurring antibody.
Lu^{b is what type of antibody?}

Usually is an Alloantibody and is clinically significant!
What is the significance of Anti-Lu^b?

This has caused Transfusion reactions and Mild HDN.

If blood is needed, you would need to contact the reference lab.

You must provide antigen negative blood!
For Lu^b give:
Clinical Significance
Antibody Class
Optimal Temp
Raction Phase
Enzyme affectiveness
- Lu^b :clinically significant
- IgG
- Can react at all temp ranges.
- Phase: RT & AHG
- Enzymes: no change either way
For Lu^alist:
Clinical Significance
Antibody Class
Optimal Temp
Reaction Phase
Enzyme Affectiveness
- Not clinically significant
- IgM can be IgG
- RT
- RT & AHG
- No change with Enzymes

Author

Kwalke12

195210

Card Set

Lutheran BG System

Description

Lutheran

Updated

2013-01-25T20:20:02Z

Show Answers