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Haematology2.txt
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what is the inheritance of haemophilia A? which factor deficiency? which pathway?
X linked recessive - so more men
factor 8
intrinsic pathway
what is haemophilia B otherwise known as?
Christmas disease
factor 9 deficiency
how do you treat haemophilia a?
replace F8 with recombinant F8
what are the symptoms of haemophilia?
bleed into joints
: haemarthrosis
bleed into muscles
: haematoma which lead to NERVE palsy and COMPARTMENT syndrome due to PRESSURE
how should vaccines be given to haemophiliacs?
subcute
never im as bleed!
what 2 tests are done for diagnosis of haemophilia? and results?
increased APTT
reduced factor
if someone has a warfarin allergy, what can they use instead?
phenindione: MOA vit K antagonist
which rash is assoc. with antiphospholipid syndrome?
livedo reticularis on legs
what is the treatment for A severe pulmonary embolism affecting a central pulmonary artery ?
thrombolysis or even embolectomy
emergency!! don't delay for imaging
what type of anaemia would you expect an epileptic on phenytoin to have? and why?
megaloblastic anaemia
phenytoid impairs folate metabolism
: get functional folate deficiency
from a FBC, how would you differentiate an iron deficiency anaemia from thalassaemia?
in thalassaemia: inc red cell count
what is HbA2?
made of 2alpha and 2delta globins due to lack of beta globins in b-thalassaemia
which disorders can cause hypersegmented neutrophils?
megaloblastic anaemia
uraemia
liver disease
when do target cells come apparent?
iron deficiency
haemolysis
Hbopathies
Liver disese
Author
kavinashah
ID
19521
Card Set
Haematology2.txt
Description
haemat
Updated
2010-05-16T23:11:45Z
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