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Autocoids

  1. Chlorpheniramine
    First generation H1 blocker
  2. Cyproheptadine
    First generation H1 blocker
  3. Diphenhydramine
    First generation H1 blocker
  4. Hydroxyzine
    First generation H1 blocker
  5. Promethazine
    First generation H1 blocker
  6. Pyrilamine
    First generation H1 blocker
  7. Chlorpromazine
    First generation H1 blocker
  8. Cyclizine
    First generation H1 blocker
  9. Cyproheptadine - special mechanism
    5-HT receptor blocker
  10. Promethazine - special mechanism
    alpha-adrenergic blocker
  11. First generation H1 blocker
    adverse effects
    • Strong sedation
    • ANS blocking activity
  12. First generation H1 blocker
    Uses
    • allergy reactions
    • decongestant
    • vomiting
    • sedation, hypnosis
  13. What should be used with H1 blockers for decongestant
    a1-adrenergic agonist
  14. Fexofenadine
    Second generation H1 blocker
  15. Loratadine
    Second generation H1 blocker
  16. Cetirizine
    Second generation H1 blocker
  17. Azelastine
    Second generation H1 blocker
  18. Astemizole
    Second generation H1 blocker
  19. Terfenadine
    Second generation H1 blocker
  20. What is different between 2nd generation vs 1st generation H1 blockers
    • 2nd generation is more specific
    • does not cross BBB
    • longer 1/2 life
  21. what is unique adverse effect of Cetirizine
    drowsiness (not commonly seen in 2nd generation H1 blockers)
  22. Unique adverse effect of Astemizole & Terfenadine
    long QT syndrome & arrhythmias (w/ CYP3A4 inhibitors)
  23. Alprostadil
    • PGE1 analog
    • maintain ductus arteriosus
    • treat erectile dysfunction
  24. Dinoprostone
    • PGE2 analog
    • cause abortion
    • induce labor
    • stop postpartum hemorrhage
  25. Carboprost
    • PGF2a analog
    • cause abortion
  26. Epoprostenol
    • PGI2
    • treat pulmonary hypertension
  27. Misoprostol
    • PGE1 analog
    • prevent & treat gastric ulcer from NSAID
    • cause abortion
  28. Latanoprost
    • PGF2a analog
    • treat glaucoma
  29. Montelukast
    Leukotriene receptor antagonist
  30. Zafirlukast
    Leukotriene receptor antagonist
  31. Zileuton
    Lipooxygenase inhibitor
  32. Cromolyn sodium
    mast cell stabilizers
  33. Nedocromil
    mast cell stabilizers
  34. Olopatadine
    • mast cell stabilizers
    • specific for eye allergy
Author
xinchen3
ID
194837
Card Set
Autocoids
Description
drugs
Updated

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